Clomiphene Best for PCOS Infertility
Researchers Say Clomiphene More Effective Than Metformin for Treatment of Polycystic Ovary Syndrome
WebMD News Archive
Feb. 7, 2007 -- One of the oldest treatments for a common cause of
infertility is still the best treatment, according to findings from a study
that experts say will have a major impact on clinical practice.
The ovulation-stimulating drug clomiphene --
used in the U.S. to treat infertility for the past four decades -- was found to
be more effective than the diabetes drug
metformin for the treatment of polycystic ovary syndrome (PCOS)-related
Metformin has become the leading treatment for PCOS, despite the fact that
it has not been approved for this purpose and had not been rigorously studied
in infertile patients with the disorder until now.
One brand name of metformin is Glucophage; researchers in the study used
Glucophage XR -- an extended release form of the drug.
Experts agree that the large, government-funded study proves that clomiphene
is the best first-line treatment for PCOS-related infertility.
The study appears in the Feb. 8 issue of the New EnglandJournal
“The findings are unequivocal,” National Institute of Child Health and Human
Development program director Tracy Rankin tells WebMD. “Metformin has been used
off label for years in the treatment of these patients, based largely on
anecdotal evidence that it works.”
‘Not as Good as We Thought’
Polycystic ovary syndrome is a leading cause of infertility. Some studies
suggest that it is the most common cause of female infertility.
PCOS is a hormonal disorder, which can interfere with ovulation when the
ovary releases an egg. Ovaries can become enlarged and develop cysts. Women with the disorder may also experience
irregular menstrual periods and excessive body and facial hair growth.
Obesity is also common among women with
PCOS, as is the prediabetic condition known as insulin
The thinking has been that drugs which help sensitize the body to insulin,
like metformin, increase ovulation in women with PCOS, and, in turn, help these
women achieve viable pregnancies.
Some small studies suggested that metformin worked better than clomiphene,
which promotes ovulation by stimulating the release of specific hormones.
The newly published study included 626 infertile women with PCOS, randomly
assigned to treatment with metformin, clomiphene, or a combination of the two
drugs for up to six months. The women didn't know which exact treatment they
Women who became pregnant were followed until delivery or pregnancy loss.
The live birth rate among the women in the study who took only metformin was
only 7%. Roughly 22% of the women who took only clomiphene gave birth, as did
27% of women who took both drugs.
The improvement in outcomes with the combination treatment did not reach
statistical significance -- compared to clomiphene alone -- says researcher
Richard S. Legro, MD.
Clomiphene Ovulations Better
“The message that this study sends is that metformin isn’t as good as we
thought it was and it should definitely not be used as a first-line, single
therapy for infertility,” Legro tells WebMD.