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Infertility: Problems With the Man's Reproductive System - Topic Overview

The most common cause of male infertility is low sperm count. Absence of sperm in the semen is less common, affecting 1 out of 100 men and affecting 10 to 15 out of 100 infertile men.1h

Causes of sperm count problems include:

  • Hormonal problems in the testicles or pituitary gland. The pituitary gland releases hormones that stimulate the testicles to produce testosterone.
  • Testicular injury or failure, either present at birth (congenital) or associated with radiation or toxic chemical exposure.
  • Cancer treatment with certain kinds of chemotherapy or radiation.
  • Antibodies that attack sperm and that also may be present in semen. Sperm antibodies sometimes develop when a man's sperm has been exposed to his immune system (outside of the testicles). This may happen after a vasectomy, an infection, or an injury to the testicles.2
  • Drug use (some prescription medicines, and marijuana and tobacco use).
  • Structural problems. These include:
  • Chromosomal problems (such as Klinefelter syndrome).
  • Genetic problems.

See a picture of the male reproductive system camera.gif.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Medical Reference from Healthwise

    Last Updated: November 14, 2013
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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