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Urease Inhibitors for Kidney Stones

Examples

Generic Name Brand Name
acetohydroxamic acid Lithostat

How It Works

Urease inhibitors dissolve crystals and struvite kidney stones and prevent the formation of new crystals in the urine.

Why It Is Used

Urease inhibitors are used to dissolve kidney stones (including struvite stones), prevent crystals from forming new kidney stones, and treat urinary tract infections.

How Well It Works

Urease inhibitors may keep some struvite stones from coming back.1

Side Effects

All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Here are some important things to think about:

  • Usually the benefits of the medicine are more important than any minor side effects.
  • Side effects may go away after you take the medicine for a while.
  • If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

Call911or other emergency services right away if you have:

Call your doctor if you have:

Common side effects of this medicine include:

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Drinking alcohol when taking this medicine may cause a skin rash. The rash usually goes away after an hour. Call your doctor if you get a skin rash when taking this medicine.

Do not take iron supplements or vitamins containing iron while taking urease inhibitors.

Taking medicine

Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.

There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.

Advice for women

Do not use this medicine if you are pregnant, breast-feeding, or planning to get pregnant. If you need to use this medicine, talk to your doctor about how you can prevent pregnancy.

Checkups

Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.

Citations

  1. Agency for Healthcare Research and Quality (2012). Recurrent Nephrolithiasis in Adults: Comparative Effectiveness of Preventive Medical Strategies (AHRQ Publication No. 12-EHC049-EF). Rockville, MD: Agency for Healthcare Research and Quality. Also available online: http://effectivehealthcare.ahrq.gov/ehc/products/274/1035/kidney-stones-prevention-report-130409.pdf.

By Healthwise Staff
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer Tushar J. Vachharajani, MD, FASN, FACP - Nephrology
Current as of May 2, 2013

WebMD Medical Reference from Healthwise

Last Updated: May 02, 2013
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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