Skip to content

    Lung Cancer Health Center

    Font Size
    A
    A
    A

    Non-Small-Cell Lung Cancer: Advances in Treatment

    By
    WebMD Feature
    Reviewed by William Blahd, MD

    A decade ago, chemotherapy was the only drug doctors could prescribe to someone with non-small-cell lung cancer (NSCLC). Not only does today’s chemotherapy work better than past versions, but there are also two new kinds of medications to treat this disease.

    One group of drugs changes the way certain cancer cells grow or change in your body. This is called targeted therapy. Others boost your immune system to better fight cancer. This is called immunotherapy.

    Recommended Related to Lung Cancer

    Understanding Lung Cancer -- Symptoms

    In its early stages, lung cancer normally has no symptoms. When symptoms start to appear, they are usually caused by blocked breathing passages or the spread of cancer further into the lung, surrounding structures, other parts of the body. Lung cancer symptoms may include: Chronic, hacking, raspy coughing, sometimes with blood-streaked mucus Recurring respiratory infections, including bronchitis or pneumonia Increasing shortness of breath, wheezing, persistent chest pain Hoars...

    Read the Understanding Lung Cancer -- Symptoms article > >

    Chemotherapy

    The word chemotherapy may make you think of unpleasant side effects like nausea and vomiting. Although some patients today have those symptoms, today's drugs cause less of them than in years past.

    “Patients are tolerating chemotherapy better, partly because we have better supportive medication and better anti-nausea medication,” says Kenneth Ng, MD, chief of medical oncology at Memorial Sloan Kettering Cancer Center Rockville Centre in New York.

    Sometimes chemo does cause fatigue, depression, nerve problems, memory problems, or hair loss. That’s because of the way that the drugs work.

    “Chemotherapy actually kills the cancer cells, but it doesn't only kill cancer cells, it kills normal cells, as well,” says Shakun Malik, MD, at the National Cancer Institute's Cancer Therapy Evaluation Program.

    But there is chemo for NSCLC that doesn't cause hair loss, and memory problems can be milder for some people. This applies to both the new drugs and updated versions of the old drugs. “It's better compared to before,” Ng says.

    You’re likely to get more than one type of chemo drug to start with. That’s the new standard of care, and it packs a powerful punch. “Combining two to three different chemotherapy drugs works better than giving one chemotherapy drug,” Ng says.

    Targeted Therapy

    A decade ago, doctors began to treat some NSCLC with these types of drugs. They target cells that have certain types of genetic information and kill these cancer cells without harming healthy ones around them.

    Doctors will take a sample of your tumor through a biopsy or surgery. Then they’ll see if the cancer cells will respond to one of these drugs. About 15% to 20% of people with NSCLC can get targeted therapy. If you’ve never smoked, the odds are even better that it’ll work for you.

    Today on WebMD

    Xray analysis
    Do you know the myths from the facts?
    chest x-ray
    Get to know them.
     
    woman taking pills
    Tips to managing them.
    Lung cancer xray
    See it in pictures, plus read the facts.
     
    Lung Cancer Risks Myths and Facts
    SLIDESHOW
    Woman getting ct scan
    Article
     
    Improving Lung Cancer Survival Targeted Therapy
    VIDEO
    cancer fighting foods
    Article
     
    Lung Cancer Surprising Differences Between Sexes
    VIDEO
    Pets Improve Your Health
    SLIDESHOW
     
    Vitamin D
    SLIDESHOW
    Lung Cancer Surgery Options
    VIDEO