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    Non-Small-Cell Lung Cancer: Advances in Treatment

    WebMD Feature
    Reviewed by William Blahd, MD

    Chemotherapy once was the only medicine doctors could prescribe to someone with non-small-cell lung cancer (NSCLC). Times have changed. Today’s chemotherapy works better, and there are two new kinds of medications to treat this disease.

    One group of drugs changes the way certain cancer cells grow or change in your body. Doctors call this targeted therapy. The other boosts your immune system to better fight cancer. It's called immunotherapy.

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    Lung Cancer Treatments

    Your doctors will plan your lung cancer treatment based on what you need. It will depend in part on: What type of the disease you have Its stage Whether the cancer has spread in your body The side effects the treatment may cause Your age and general health Your preferences and goals Ask your doctor to explain the recommended treatment plan, including its benefits, side effects, and how it might make you feel during and after it.

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    Just the word may make you think of unpleasant side effects like nausea and vomiting. Although that can still happen, there are better medicines to tame it, says Kenneth Ng, MD, chief of medical oncology at Memorial Sloan Kettering Rockville Centre in New York.

    Sometimes chemo does cause fatigue, depression, nerve problems, memory problems, or hair loss. They happen because of the way the drugs work.

    “Chemotherapy actually kills the cancer cells, but it doesn't only kill cancer cells, it kills normal cells as well,” says Shakun Malik, MD, at the National Cancer Institute's Cancer Therapy Evaluation Program.

    But there is chemo for NSCLC that doesn't cause hair loss, and memory problems can be milder for some people. That’s true for newer chemo drugs and updated versions of older ones. “It's better compared to before,” Ng says.

    You’re likely to get more than one type of chemo drug to start with. That’s routine now. “Combining two to three different chemotherapy drugs works better than giving one chemotherapy drug,” Ng says.

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