Lung cancer is responsible for the most cancer-related deaths for both men and women throughout the world. The American Cancer Society estimated that 228,190 new cases of lung cancer in the U.S. were diagnosed and 159,480 deaths due to lung cancer occurred in 2013.
Lung cancer was not common prior to the 1930s, but increased dramatically over the following decades as tobacco smoking increased. In many developing countries, the incidence of lung cancer is beginning to fall because of education about the dangers of cigarette smoking and effective smoking cessation programs. Nevertheless, lung cancer remains the most common form of cancer in men worldwide and the fifth most common form of cancer in women.
Standard Treatment Options for Recurrent NSCLC
Standard treatment options for recurrent NSCLC include the following:
Radiation therapy (for palliation).
Chemotherapy or kinase inhibitors alone, including the following for patients who have previously received platinum chemotherapy:Docetaxel.[2,3]Pemetrexed.Erlotinib after failure of both platinum-based and docetaxel chemotherapies.Gefitinib.Crizotinib for EML4-ALK translocations.[6,7]
EGFR inhibitors in...