Lung cancer is responsible for the most cancer-related deaths for both men and women throughout the world. The American Cancer Society estimated that 228,190 new cases of lung cancer in the U.S. were diagnosed and 159,480 deaths due to lung cancer occurred in 2013.
Lung cancer was not common prior to the 1930s, but increased dramatically over the following decades as tobacco smoking increased. In many developing countries, the incidence of lung cancer is beginning to fall because of education about the dangers of cigarette smoking and effective smoking cessation programs. Nevertheless, lung cancer remains the most common form of cancer in men worldwide and the fifth most common form of cancer in women.
In NSCLC, the determination of stage is important in terms of therapeutic and prognostic implications. Careful initial diagnostic evaluation to define the location and to determine the extent of primary and metastatic tumor involvement is critical for the appropriate care of patients.
In general, symptoms, physical signs, laboratory findings, or perceived risk of distant metastasis lead to an evaluation for distant metastatic disease. Additional tests such as bone scans and computed...