Lung cancer is responsible for the most cancer-related deaths for both men and women throughout the world. The American Cancer Society estimated that 228,190 new cases of lung cancer in the U.S. were diagnosed and 159,480 deaths due to lung cancer occurred in 2013.
Lung cancer was not common prior to the 1930s, but increased dramatically over the following decades as tobaccosmoking increased. In many developing countries, the incidence of lung cancer is beginning to fall because of education about the dangers of cigarette smoking and effective smoking cessation programs. Nevertheless, lungcancer remains the most common form of cancer in men worldwide and the fifth most common form of cancer in women.
Small cell lung cancer (SCLC) accounts for approximately 15% of bronchogenic carcinomas.
At the time of diagnosis, approximately 30% of patients with SCLC will have tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes. These patients are designated as having limited-stage disease (LD). Patients with tumors that have spread beyond the supraclavicular areas are said to have extensive-stage disease (ED).
SCLC is more responsive to chemotherapy and radiation...