In occult lung cancer, a diagnostic evaluation often includes chest x-ray and selective bronchoscopy with close follow-up (e.g., computed tomography scan), when needed, to define the site and nature of the primary tumor; tumors discovered in this fashion are generally early stage and curable by surgery.After discovery of the primary tumor, treatment involves establishing the stage of the tumor. Therapy is identical to that recommended for other NSCLC patients with similar stage disease. Standard Treatment Options for Occult NSCLCStandard treatment options for occult NSCLC include the following:Surgery.Current Clinical TrialsCheck for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with occult non-small cell lung cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.General information about clinical trials is also available from the NCI Web site.
Standard Treatment Options for Recurrent NSCLCStandard treatment options for recurrent NSCLC include the following: Radiation therapy (for palliation).Chemotherapy or kinase inhibitors alone, including the following for patients who have previously received platinum chemotherapy:Docetaxel.[2,3]Pemetrexed.Erlotinib after failure of both platinum-based and docetaxel chemotherapies.Gefitinib.Crizotinib for EML4-ALK translocations.[6,7]EGFR inhibitors in patients with or without EGFR mutations.EML4-ALK inhibitors in patients with EML-ALK translocations.Surgical resection of isolated cerebral metastasis (for highly selected patients).Laser therapy or interstitial radiation therapy (for endobronchial lesions).Stereotactic radiation surgery (for highly selected patients).[10,11]Radiation therapy may provide excellent palliation of symptoms from a localized tumor mass.The use of chemotherapy has produced objective responses and small