Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Extensive-Stage Small Cell Lung Cancer Treatment
Standard Treatment Options for Patients With Extensive-Stage Small Cell Lung Cancer (SCLC)Standard treatment options for patients with extensive-stage SCLC include the following:Combination chemotherapy.Radiation therapy.Prophylactic cranial irradiation.Combination chemotherapyChemotherapy for patients with extensive-stage disease (ED) SCLC is commonly given as a two-drug combination of platinum and etoposide in doses associated with at least moderate toxic effects (as in limited-stage [LD] SCLC). Cisplatin is associated with significant toxic effects and requires fluid hydration, which can be problematic in patients with cardiovascular disease. Carboplatin is active in SCLC, is dosed according to renal function, and is associated with less nonhematological toxic effects.Other regimens appear to produce similar survival outcomes but have been studied less extensively or are in less common use.Table 2. . Combination Chemotherapy For Extensive-Stage Small Cell
Small Cell Lung Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Get More Information From NCI
Call 1-800-4-CANCERFor more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.Chat online The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist. The service is available from 8:00 a.m. to 11:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. Write to usFor more information from the NCI, please write to this address:NCI Public Inquiries Office9609 Medical Center Dr. Room 2E532 MSC 9760Bethesda, MD 20892-9760Search the NCI Web siteThe NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support
Lung Cancer - General Information About Small Cell Lung Cancer
Small cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung. The lungs are a pair of cone-shaped breathing organs that are found within the chest. The lungs bring oxygen into the body when breathing in and take out carbon dioxide when breathing out. Each lung has sections called lobes. The left lung has two lobes. The right lung,which is slightly ...
Small Cell Lung Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (05 / 02 / 2014)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Editorial changes were made to this summary.
Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Recurrent NSCLC Treatment
Standard Treatment Options for Recurrent NSCLCStandard treatment options for recurrent NSCLC include the following: Radiation therapy (for palliation).Chemotherapy or kinase inhibitors alone, including the following for patients who have previously received platinum chemotherapy:Docetaxel.[2,3]Pemetrexed.Erlotinib after failure of both platinum-based and docetaxel chemotherapies.Gefitinib.Crizotinib for EML4-ALK translocations.[6,7]EGFR inhibitors in patients with or without EGFR mutations.EML4-ALK inhibitors in patients with EML-ALK translocations.Surgical resection of isolated cerebral metastasis (for highly selected patients).Laser therapy or interstitial radiation therapy (for endobronchial lesions).Stereotactic radiation surgery (for highly selected patients).[10,11]Radiation therapy may provide excellent palliation of symptoms from a localized tumor mass.The use of chemotherapy has produced objective responses and small
Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Option Overview
There are different types of treatment for patients with non-small cell lung cancer.Different types of treatments are available for patients with non-small cell lung cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.Nine types of standard treatment are used:Surgery Four types of surgery are used to treat lung cancer:Wedge resection: Surgery to remove a tumor and some of the normal tissue around it. When a slightly larger amount of tissue is taken, it is called a segmental resection.Wedge
Small Cell Lung Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Options for Recurrent Non-Small Cell Lung Cancer
Treatment of recurrent non-small cell lung cancer may include the following:External radiation therapy as palliative therapy, to relieve pain and other symptoms and improve the quality of life.Chemotherapy.Targeted therapy with a tyrosine kinase inhibitor.Laser therapy or internal radiation therapy using an endoscope.Radiosurgery (for certain patients who cannot have surgery).Surgery to remove a very small amount of cancer that has spread to the brain.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent non-small cell lung cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
Lung Cancer Screening - About This PDQ Summary
About PDQPhysician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government's center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.Purpose of This SummaryThis PDQ cancer information summary has current
Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Localized Malignant Mesothelioma (Stage I)
Standard treatment options: Solitary mesotheliomas: Surgical resection en bloc including contiguous structures to ensure wide disease-free margins. Sessile polypoid lesions should be treated with surgical resection to ensure maximal potential for cure. Intracavitary mesothelioma:Palliative surgery (i.e., pleurectomy and decortication) with or without postoperative radiation therapy.Extrapleural pneumonectomy.Palliative radiation therapy.Treatment options under clinical evaluation: Intracavitary chemotherapy following resection.[3,4]Multimodality therapy.[4,5,6]Other clinical trials.Current Clinical TrialsCheck for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with localized malignant mesothelioma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.General information about clinical trials is also available from the NCI Web site.References: Antman KH, Li FP, Osteen R, et al.:
Small Cell Lung Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - To Learn More About Small Cell Lung Cancer
For more information from the National Cancer Institute about small cell lung cancer, see the following:Lung Cancer Home PageWhat You Need to Know About™ Lung CancerLung Cancer PreventionLung Cancer ScreeningDrugs Approved for Small Cell Lung CancerSmoking Home Page (Includes help with quitting)Cigarette Smoking: Health Risks and How to QuitSmoking in Cancer CareSecondhand Smoke and CancerFor general cancer information and other resources from the National Cancer Institute, see the following:What You Need to Know About™ CancerUnderstanding Cancer Series: CancerCancer StagingChemotherapy and You: Support for People With CancerRadiation Therapy and You: Support for People With CancerCoping with Cancer: Supportive and Palliative CareQuestions to Ask Your Doctor About CancerCancer LibraryInformation For Survivors/Caregivers/Advocates