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    Lung Cancer Health Center

    Medical Reference Related to Lung Cancer

    1. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Stage IIIB NSCLC Treatment

      Based on the Surveillance, Epidemiology, and End Registry, the estimated incidence of stage IIIB NSCLC is 17.6%.[1] The anticipated 5-year survival for the vast majority of patients who present with clinical stage IIIB NSCLC is 3% to 7%.[2] In small case series, selected patients with T4, N0-1 disease, solely as the result of satellite tumor nodule(s) within the primary lobe, have been reported to have 5-year survival rates of 20%.[3,4][Level of evidence: 3iiiA]Standard Treatment Options for Stage IIIB NSCLCStandard treatment options for stage IIIB NSCLC include the following:Sequential or concurrent chemotherapy and radiation therapy.Chemotherapy followed by surgery (for selected patients).Radiation therapy alone.For treatment of locally advanced unresectable tumor in patients who are not candidates for chemotherapy.For patients requiring palliative treatment.In general, patients with stage IIIB NSCLC do not benefit from surgery alone and are best managed

    2. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Cellular Classification of NSCLC

      Malignant non-small cell epithelial tumors of the lung are classified by the World Health Organization (WHO)/International Association for the Study of Lung Cancer (IASLC). There are three main subtypes of non-small cell lung cancer (NSCLC), including the following: Squamous cell carcinoma (25% of lung cancers).Adenocarcinoma (40% of lung cancers).Large cell carcinoma (10% of lung cancers). There are numerous additional subtypes of decreasing frequency.[1]WHO/IASLC Histologic Classification of NSCLCSquamous cell carcinoma.Papillary.Clear cell.Small cell.Basaloid.Adenocarcinoma.Acinar.Papillary.Bronchioloalveolar carcinoma. Nonmucinous.Mucinous.Mixed mucinous and nonmucinous or indeterminate cell type.Solid adenocarcinoma with mucin.Adenocarcinoma with mixed subtypes.Variants.Well-differentiated fetal adenocarcinoma.Mucinous (colloid) adenocarcinoma.Mucinous cystadenocarcinoma.Signet ring adenocarcinoma.Clear cell adenocarcinoma.Large cell carcinoma.Variants.Large cell

    3. Small Cell Lung Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Questions or Comments About This Summary

      If you have questions or comments about this summary, please send them to Cancer.gov through the Web site's Contact Form. We can respond only to email messages written in English.

    4. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Get More Information From NCI

      Call 1-800-4-CANCERFor more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.Chat online The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist. The service is available from 8:00 a.m. to 11:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. Write to usFor more information from the NCI, please write to this address:NCI Public Inquiries Office9609 Medical Center Dr. Room 2E532 MSC 9760Bethesda, MD 20892-9760Search the NCI Web siteThe NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support

    5. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - nci_ncicdr0000062932-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Non-Small Cell Lung Cancer Treatment

    6. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - nci_ncicdr0000062825-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Lung Cancer Prevention

    7. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Changes to This Summary (08 / 06 / 2014)

      The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Stages IA and IB NSCLC TreatmentAdded text to state that a substantial number of patients are ineligible for standard surgical resection because of comorbid conditions that are associated with unacceptably high perioperative risk; observation and radiation therapy may be considered for these patients (cited McGarry et al., Lanni et al., and Grutterset al. as reference 22, reference 23, and reference 24, respectively). Also added text to state that nonrandomized observation studies comparing treatment outcomes associated with resection, radiation therapy, and observation have demonstrated shorter survival times and higher mortality for patients treated with observation only, there are a number of approaches to delivery of radiation therapy, and there are limited reliable data from comparative

    8. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Stages IIA and IIB NSCLC Treatment

      Standard Treatment Options for Stages IIA and IIB NSCLCStandard treatment options for stages IIA NSCLC and IIB NSCLC include the following:Surgery.Neoadjuvant chemotherapy.Adjuvant chemotherapy.Radiation therapy.Adjuvant radiation therapy has not been show to improve outcomes in patients with stages II NSCLC.SurgerySurgery is the treatment of choice for patients with stage II NSCLC. A lobectomy, pneumonectomy, or segmental resection, wedge resection, or sleeve resection may be performed as appropriate. Careful preoperative assessment of the patient's overall medical condition, especially the patient's pulmonary reserve, is critical in considering the benefits of surgery. Despite the immediate and age-related postoperative mortality rate, a 5% to 8% mortality rate with pneumonectomy or a 3% to 5% mortality rate with lobectomy can be expected. Evidence (surgery):The Cochrane Collaboration group reviewed 11 randomized trials with a total of

    9. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - nci_ncicdr0000062832-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Lung Cancer Screening

    10. Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - General Information About Malignant Mesothelioma Treatment

      Prognosis in this disease is difficult to assess consistently because there is great variability in the time before diagnosis and the rate of disease progression. In large retrospective series of pleural mesothelioma patients,important prognostic factors were found to be:[ 1,2 ] Stage. Age. Performance status. Histology. Various surgical procedures may be possible in selected patients,...

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