Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage IV NSCLC Treatment
Forty percent of patients with newly diagnosed non-small cell lung cancer (NSCLC) have stage IV disease. Treatment goals are to prolong survival and control disease-related symptoms. Treatment options include cytotoxic chemotherapy and targeted agents. Factors influencing treatment selection include comorbidity, performance status (PS), histology, and molecular genetic features of the cancer. Radiation therapy and surgery are generally used in selective cases for symptom palliation.Standard Treatment Options for Stage IV NSCLCStandard treatment options for stage IV NSCLC include the following:Cytotoxic combination chemotherapy (first line) with platinum (cisplatin or carboplatin) and paclitaxel, gemcitabine, docetaxel, vinorelbine, irinotecan, and pemetrexed. Factors influencing treatment.Histology.Age versus comorbidity.PS.Combination chemotherapy with
Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - nci_ncicdr0000062895-nci-header
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Malignant Mesothelioma Treatment
Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - To Learn More About Non-Small Cell Lung Cancer
For more information from the National Cancer Institute about non-small cell lung cancer, see the following: Lung Cancer Home PageWhat You Need To Know About™ Lung CancerLung Cancer PreventionLung Cancer ScreeningDrugs Approved for Non-Small Cell Lung CancerUnderstanding Cancer Series: Targeted Therapies (Advances in Targeted Therapies)Targeted Cancer TherapiesLasers in Cancer TreatmentPhotodynamic Therapy for CancerSmoking Home Page (Includes help with quitting)Secondhand Smoke and CancerFor general cancer information and other resources from the National Cancer Institute, see the following:What You Need to Know About™ CancerUnderstanding Cancer Series: CancerCancer StagingChemotherapy and You: Support for People With CancerRadiation Therapy and You: Support for People With CancerCoping with Cancer: Supportive and Palliative CareQuestions to Ask Your Doctor About CancerCancer LibraryInformation For Survivors/Caregivers/Advocates
Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - What is prevention?
Cancerprevention is action taken to lower the chance of getting cancer. By preventing cancer,the number of new cases of cancer in a group or population is lowered. Hopefully,this will lower the number of deaths caused by cancer. To prevent new cancers from starting,scientists look at risk factors and protective factors. Anything that increases your chance of developing cancer is called a ...
Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Options by Stage
A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Limited-Stage Small Cell Lung CancerTreatment of limited-stage small cell lung cancer may include the following:Combination chemotherapy and radiation therapy to the chest. Radiation therapy to the brain may later be given to patients with complete responses.Combination chemotherapy alone for patients who cannot be given radiation therapy.Surgery followed by chemotherapy.Surgery followed by chemotherapy and radiation therapy.Radiation therapy to the brain may be given to patients who have had a complete response, to prevent the spread of cancer to the brain.Clinical trials of new chemotherapy, surgery, and radiation treatments.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with
Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Limited-Stage Small Cell Lung Cancer Treatment
Standard Treatment Options for Patients With Limited-Stage Small Cell Lung Cancer (SCLC)Standard treatment options for patients with limited-stage SCLC include the following:Chemotherapy and radiation therapy.Combination chemotherapy alone.Surgery followed by chemotherapy or chemoradiotherapy.Prophylactic cranial irradiation.Chemotherapy and radiation therapyCombined-modality treatment with etoposide and cisplatin with thoracic radiation therapy (TRT) is the most widely used treatment for patients with limited-stage disease (LD) SCLC.Evidence (combined modality treatment):Survival. The following results have been reported in clinical trials:Mature results of prospective randomized trials suggest that combined-modality therapy produces a modest but significant improvement in survival of 5% at 3 years compared with chemotherapy alone.[1,2,3][Level of evidence: 1iiA]Clinical trials have consistently achieved median survivals of 18 to 24 months and 40% to 50% 2-year survival
Lung Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Overview
Separate PDQ summaries on Lung Cancer Prevention, Small Cell Lung Cancer Treatment, Non-Small Cell Lung Cancer Treatment, and Levels of Evidence for Cancer Screening and Prevention Studies are also available.Evidence of Benefit Associated With ScreeningScreening by low-dose helical computed tomographyBenefitsThere is evidence that screening persons aged 55 to 74 years who have cigarette smoking histories of 30 or more pack-years and who, if they are former smokers, have quit within the last 15 years reduces lung cancer mortality by 20% and all-cause mortality by 6.7%.Magnitude of Effect: 20% relative reduction in lung cancer–specific mortality. Study Design: Evidence obtained from a randomized controlled trial.Internal Validity: Good.Consistency: Not applicable—one randomized trial to date.External Validity: Fair.HarmsBased on solid evidence, screening would lead to false-positive tests in approximately one-quarter of those screened. Most abnormalities would be monitored
Lung Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] - Lung Cancer Prevention
Avoiding risk factors and increasing protective factors may help prevent lung cancer.Avoiding cancer risk factors may help prevent certain cancers. Risk factors include smoking, being overweight, and not getting enough exercise. Increasing protective factors such as quitting smoking, eating a healthy diet, and exercising may also help prevent some cancers. Talk to your doctor or other health care professional about how you might lower your risk of cancer.The following are risk factors for lung cancer:Cigarette, cigar, and pipe smoking Tobacco smoking is the most important risk factor for lung cancer. Cigarette, cigar, and pipe smoking all increase the risk of lung cancer. Tobacco smoking causes about 9 out of 10 cases of lung cancer in men and about 8 out of 10 cases of lung cancer in women.Studies have shown that smoking low tar or low nicotine cigarettes does not lower the risk of lung cancer. Studies also show that the risk of lung cancer from smoking cigarettes increases with the
Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Options for Recurrent Non-Small Cell Lung Cancer
Treatment of recurrent non-small cell lung cancer may include the following:External radiation therapy as palliative therapy, to relieve pain and other symptoms and improve the quality of life.Chemotherapy.Targeted therapy with a tyrosine kinase inhibitor.Laser therapy or internal radiation therapy using an endoscope.Radiosurgery (for certain patients who cannot have surgery).Surgery to remove a very small amount of cancer that has spread to the brain.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent non-small cell lung cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
Small Cell Lung Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (12 / 03 / 2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. Editorial changes were made to this summary.