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    Guided Heat for Inoperable Lung Cancer

    Procedure Called RF Ablation as Effective as Radiation for Some Patients, Study Reports
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    March 27, 2007 -- A minimally invasive treatment that uses guided heat to kill cancer cells shows promise as an alternative to radiation in patients with inoperable, early-stage lung cancers.

    Researchers say radiofrequency (RF) ablation may offer older, sicker patients who are not good candidates for surgery an easier-to-tolerate treatment than radiation.

    That's their conclusion after a study looking at 153 lung cancer patients with inoperable disease who were treated with RF ablation.

    Of those with stage I disease, or early-stage cancer confined to the lung, 57% lived for at least two years following the treatment. Three-year survival was 36% in the patients, who generally had other serious health problems such as emphysema or heart disease.

    “We showed that RF ablation can result in decent outcomes even in this very frail and sick population,” Damian E. Dupuy, MD, tells WebMD.

    Single-Day Treatment

    RF ablation has been used in the United States for a decade, most often for the treatment of patients with liver, kidney, colon, and bone cancers who are not good candidates for other treatments.

    The procedure involves positioning an image-guided needle within the tumor to transmit mild, painless radiofrequency energy similar to microwave heat. The aim is to kill tumor cells with heat while leaving surrounding tissue relatively unharmed.

    RF ablation is generally performed in a single day in an outpatient setting. Conventional external beam radiation (EBT) involves as many as 33 treatments delivered over six weeks.

    "It is important for physicians to know that RF ablation is a treatment option for their sickest and elderly patients," Dupuy says.

    In the newly reported study, published in the April issue of Radiology, Dupuy and colleagues used RF ablation to treat 116 patients with primary lung cancers and 73 patients whose primary cancers had spread to a lung.

    The one, two, three, four, and five-year survival rates for patients with stage I, non-small-cell lung cancers were 78%, 57%, 36%, 27%, and 27%, respectively.

    Survival Advantage?

    The researchers say their outcomes compared favorably with those reported in other studies of patients treated with radiation and may even show a survival advantage for RF ablation.

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