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    Tamoxifen May Cut Lung Cancer Deaths

    Study Suggests Hormones Influence Some Lung Cancers
    By
    WebMD Health News
    Reviewed by Laura J. Martin, MD

    Jan. 24, 2011 -- Tamoxifen, the medication long used to prevent the growth of breast cancer tumors, also appears to reduce the risk of dying from lung cancer, research suggests.

    If the link bears out in future studies, giving tamoxifen for lung cancer may become another option for doctors, the researchers say.

    The team of Swiss and French researchers followed more than 6,000 women diagnosed with breast cancer between 1980 and 2003. The researchers found that women on tamoxifen for their breast cancer who also contracted lung cancer were 87% less likely to die from the lung cancer than women who weren't on tamoxifen.

    "A reduction of 87% is definitely more than modest," Elisabetta Rapiti, MD, senior epidemiologist at the Geneva Cancer Registry, tells WebMD in an email interview.

    The study is published online in the journal Cancer.

    Tamoxifen for Lung Cancer: The Back Story

    The finding makes sense in the wake of previous research, Rapiti tells WebMD. In the past, research has found that hormone therapy taken during menopause increases the risk of dying from lung cancer.

    "We have seen in the laboratory that estrogens can stimulate the growth and proliferation of lung cancer cells," she says.

    So, it would follow that the tamoxifen, an “anti-estrogen,” may work against lung cancer.

    "Our findings are quite new and exciting, as they are the first to document such a strong association between the use of tamoxifen and reduced mortality of lung cancer," she says.

    The work builds on earlier studies, as far back as the late 1980s, that found evidence that estrogen may be involved in the development of lung cancer, she says, especially adenocarcinomas.

    The adenocarcinomas occur in smokers and nonsmokers and are more common in women than in men, the American Cancer Society says. The tumors are usually found in the outer region of the lung and account for about 40% of all lung cancers.

    Tamoxifen for Lung Cancer: Study Details

    Rapiti's team found that 40 women in the study -- out of a total of 6,655 -- contracted lung cancer during the follow-up, which lasted until December 2007. Although 46% of the women were prescribed tamoxifen or other anti-estrogen drugs to treat their breast cancer, 54% were not.

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