Skip to content

Lung Cancer Health Center

Font Size

Malignant Mesothelioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Localized Malignant Mesothelioma (Stage I)

Standard treatment options:[1]

  1. Solitary mesotheliomas: Surgical resection en bloc including contiguous structures to ensure wide disease-free margins. Sessile polypoid lesions should be treated with surgical resection to ensure maximal potential for cure.[2]
  2. Intracavitary mesothelioma:
    • Palliative surgery (i.e., pleurectomy and decortication) with or without postoperative radiation therapy.
    • Extrapleural pneumonectomy.
    • Palliative radiation therapy.

Treatment options under clinical evaluation:

Recommended Related to Lung Cancer

Adverse Effects

The only reported adverse effect with the use of Selected Vegetables/Sun's Soup was a feeling of fullness or bloatedness when freeze-dried Selected Vegetables (SV) was consumed in the amount specified in the phase I/II clinical trial.[1] No adverse effects were reported after ingestion of frozen SV.[2] References: Sun AS, Ostadal O, Ryznar V, et al.: Phase I/II study of stage III and IV non-small cell lung cancer patients taking a specific dietary supplement. Nutr Cancer 34...

Read the Adverse Effects article > >

  1. Intracavitary chemotherapy following resection.[3,4]
  2. Multimodality therapy.[4,5,6]
  3. Other clinical trials.

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with localized malignant mesothelioma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

References:

  1. Antman KH, Li FP, Osteen R, et al.: Mesothelioma. Cancer: Principles and Practice of Oncology Updates 3(1): 1-16, 1989.
  2. Martini N, McCormack PM, Bains MS, et al.: Pleural mesothelioma. Ann Thorac Surg 43 (1): 113-20, 1987.
  3. Markman M, Kelsen D: Efficacy of cisplatin-based intraperitoneal chemotherapy as treatment of malignant peritoneal mesothelioma. J Cancer Res Clin Oncol 118 (7): 547-50, 1992.
  4. Rusch V, Saltz L, Venkatraman E, et al.: A phase II trial of pleurectomy/decortication followed by intrapleural and systemic chemotherapy for malignant pleural mesothelioma. J Clin Oncol 12 (6): 1156-63, 1994.
  5. Sugarbaker DJ, Mentzer SJ, DeCamp M, et al.: Extrapleural pneumonectomy in the setting of a multimodality approach to malignant mesothelioma. Chest 103 (4 Suppl): 377S-381S, 1993.
  6. Vogelzang NJ: Malignant mesothelioma: diagnostic and management strategies for 1992. Semin Oncol 19 (4 Suppl 11): 64-71, 1992.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: September 04, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
    1
    Next Article:

    Today on WebMD

    Broken cigarette
    Do you know the myths from the facts?
    man with a doctor
    Our health check will steer you in the right direction.
     
    sauteed cherry tomatoes
    Fight cancer one plate at a time.
    Lung cancer xray
    See it in pictures, plus read the facts.
     
    15 Cancer Symptoms Men Ignore
    FEATURE
    Lung Cancer Risks Myths and Facts
    SLIDESHOW
     
    cancer fighting foods
    SLIDESHOW
    Improving Lung Cancer Survival Targeted Therapy
    VIDEO
     
    Lung Cancer Surprising Differences Between Sexes
    VIDEO
    Pets Improve Your Health
    SLIDESHOW
     
    Vitamin D
    SLIDESHOW
    Lung Cancer Surgery Options
    VIDEO
     

    WebMD Special Sections