Standard Treatment Options for Patients With Limited-Stage Small Cell Lung Cancer (SCLC)
Standard treatment options for patients with limited-stage SCLC include the following:
Chemotherapy and radiation therapy.
Combination chemotherapy alone.
Surgery followed by chemotherapy or chemoradiotherapy.
Prophylactic cranial irradiation.
Chemotherapy and radiation therapy
Combined-modality treatment with etoposide and cisplatin with thoracic radiation therapy (TRT) is...
Standard treatment options for stage 0 NSCLC include the following:
Endobronchial therapies, including photodynamic therapy, electrocautery, cryotherapy, and Nd-YAG laser therapy.
Segmentectomy or wedge resection are used to preserve maximum normal pulmonary tissue since patients with stage 0 NSCLC are at a high risk for second lung cancers. Because these tumors are by definition noninvasive and incapable of metastasizing, they should be curable with surgical resection; however, such lesions, when identified, are often centrally located and may require a lobectomy.
Patients with central lesions may be candidates for curative endobronchial therapy. Endobronchial therapies that preserve lung function include photodynamic therapy, electrocautery, cryotherapy, and Nd-YAG laser therapy.[3,4,5,6]
Evidence (endobronchial therapies):
Small case series have reported high complete response rates and long-term survival in selected patients.[7,8][Level of evidence: 3iiiDiii]
Efficacy of these treatment modalities in the management of patients with early NSCLC remains to be proven in definitive randomized controlled trials.
There is a high incidence of second primary cancers developing.[1,2]
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage 0 non-small cell lung cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
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