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    Non-Small Cell Lung Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for NSCLC

    Table 1. Stage Grouping Comparisons: Sixth Edition Versus Seventh Edition Descriptors, T and M Categories, and Stage Groupingsa,b

    Sixth Edition T/M Descriptor (cm) Seventh Edition T/M N0 N1 N2 N3
    T = primary tumor; N0 = no regional lymph node metastasis; N1 = metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension; N2 = metastasis in ipsilateral mediastinal and/or subcarinal lymph node(s); N3 = metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s); M = distant metastasis.
    a Cells in bold indicate a change from the sixth edition for a particular TNM category.
    b Reprinted with permission from Goldstraw P, Crowley J, Chansky K, et al.: The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours.J. Thorac Oncol 2:706-14, 2007.
    T1 (≤2) T1a IA IIA IIIA IIIB
    T1 (>2-3) T1b IA IIA IIIA IIIB
    T2 (≤5) T2a IB IIA IIIA IIIB
    T2 (>5-7) T2b IIA IIB IIIA IIIB
    T3 invasion T3 IIB IIIA IIIA IIIB
    T4 (same lobe nodules) T3 IIB IIIA IIIA IIIB
    T4 (extension) T4 IIIA IIIA IIIB IIIB
    M1 (ipsilateral lung) T4 IIIA IIIA IIIB IIIB
    T4 (pleural effusion) M1a IV IV IV IV
    M1 (contralateral lung) M1a IV IV IV IV
    M1 (distant) M1b IV IV IV IV

    AJCC Stage Groupings and TNM Definitions

    The AJCC has designated staging by TNM classification to define NSCLC.[19]

    Table 2. Definitions of TNM Occult Carcinomaa

    Stage TNM Description
    a Reprinted with permission from AJCC: Lung. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 253-70.
    Occult carcinoma TX, N0, M0 TX = Primary tumor cannot be assessed, or tumor proven by the presence of malignant cells in sputum or bronchial washings but not visualized by imaging or bronchoscopy.
    N0 = No regional lymph node metastasis.
    M0 = No distant metastasis.
    1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12
    1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12
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