In general, the worse your underlying COPD, the more often you will have exacerbations. Acute exacerbations cannot be totally prevented. However, you can decrease how often you have them and how bad they are if you manage your care well.
General guidelines for reducing exacerbations include:
Wash your hands often. It is an easy way to prevent infection. Also, avoid close contact with people who have colds or the flu.
Keep your flu and pneumonia shots up to date.