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    Cystic Fibrosis

    Important
    It is possible that the main title of the report Cystic Fibrosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • CF
    • fibrocystic disease of pancreas
    • mucoviscidosis
    • pancreatic fibrosis

    Disorder Subdivisions

    • None

    General Discussion

    Cystic fibrosis is a genetic disorder that often affects multiple organ systems of the body. Cystic fibrosis is characterized by abnormalities affecting certain glands (exocrine) of the body especially those that produce mucus. Saliva and sweat glands may also be affected. Exocrine glands secrete substances through ducts, either internally (e.g., glands in the lungs) or externally (e.g., sweat glands). In cystic fibrosis, these secretions become abnormally thick and can clog up vital areas of the body causing inflammation, obstruction and infection. The symptoms of cystic fibrosis can vary greatly in number and severity from one individual to another. Common symptoms include breathing (respiratory) abnormalities including a persistent cough, shortness of breath and lung infections; obstruction of the pancreas, which prevents digestive enzymes from reaching the intestines to help break down food and may result in poor growth and poor nutrition; and obstruction of the intestines. Cystic fibrosis is slowly progressive and often causes chronic lung damage, which eventually results in life-threatening complications. Because of improved treatments and new treatment options, the outlook and overall quality of life of individuals with cystic fibrosis has improved and more than 40 percent of individuals with the disorder are adults. Cystic fibrosis is caused by mutations to the cystic fibrosis transmembrane conductance regulator (CFTR) gene and is inherited as an autosomal recessive trait.

    Resources

    Cystic Fibrosis Foundation
    6931 Arlington Rd.
    Bethesda, MD 20814
    Tel: (301)951-4422
    Fax: (301)951-6378
    Tel: (800)344-4823
    Email: info@cff.org
    Internet: http://www.cff.org

    American Lung Association
    1301 Pennsylvania Ave NW
    Suite 800
    Washington, DC 20004
    USA
    Tel: (202)785-3355
    Fax: (202)452-1805
    Tel: (800)586-4872
    Email: info@lungusa.org
    Internet: http://www.lungusa.org

    Canadian Cystic Fibrosis Foundation
    2221 Yonge Street
    Suite 601
    Toronto
    Ontario, M1B 4G8
    Canada
    Tel: 4164859149
    Fax: 4164850960
    Tel: 8003782233
    Email: info@cysticfibrosis.ca
    Internet: http://www.cysticfibrosis.ca

    Cystic Fibrosis Trust
    11 London Rd
    Bromley
    Kent, BR1 1BY
    United Kingdom
    Tel: 02084647211
    Fax: 02083130472
    Tel: 03003731000
    Email: enquiries@cftrust.org.uk
    Internet: http://www.cftrust.org.uk

    NIH/National Institute of Diabetes, Digestive & Kidney Diseases
    Office of Communications & Public Liaison
    Bldg 31, Rm 9A06
    31 Center Drive, MSC 2560
    Bethesda, MD 20892-2560
    Tel: (301)496-3583
    Email: NDDIC@info.niddk.nih.gov
    Internet: http://www2.niddk.nih.gov/

    Cystic Fibrosis Research, Inc.
    Bayside Business Plaza
    2670 Bayshore Parkway
    Suite 520
    Mountain View, CA 94043
    USA
    Tel: (650)404-9975
    Fax: (650)404-9981
    Email: cfri@cfri.org
    Internet: http://www.cfri.org

    Cochrane Cystic Fibrosis and Genetic Disorders Group
    Institute of Child Health, University of Liverpool
    Alder Hey Children's NHS Foundation Trust
    Liverpool, L12 2 AP
    United Kingdom
    Tel: 441512525696
    Email: nikkij@liverpool.ac.uk
    Internet: http://cfgd.cochrane.org

    Cystic Fibrosis Worldwide
    Evka 3 Mahallesi
    127/19 SOKAK NO/25
    Dubleks
    Bornova, Izmir,
    Turkey
    Tel: 902323756856
    Fax: 902323756856
    Email: information@cfww.org
    Internet: http://www.cfww.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Global Fibrosis Foundation
    5036 Dr. Phillips Boulevard
    Suite 244
    Orlando, FL 32819
    Tel: (407)909-0753
    Fax: (407)909-0153
    Tel: (800)872-6874
    Email: globalfibrosis@gmail.com
    Internet: http://www.globalfibrosis.com

    Childhood Liver Disease Research and Education Network
    c/o Joan M. Hines, Research Administrator
    Children's Hospital Colorado
    13123 E 16th Ave. B290
    Aurora, CO 80045
    Tel: (720)777-2598
    Fax: (720)777-7351
    Email: joan.hines@childrenscolorado.org
    Internet: http://www.childrennetwork.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 2/6/2012
    Copyright 1984, 1985, 1986, 1987, 1988, 1989, 1990, 1991, 1992, 1994, 1995, 1996. 1997, 1998, 1999, 2000, 2002, 2007, 2009, 2011 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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