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Lung Disease & Respiratory Health Center

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Adempas Approved to Treat Pulmonary Hypertension

New drug works to ease high blood pressure in lung arteries

WebMD News from HealthDay

By Scott Roberts

HealthDay Reporter

WEDNESDAY, Oct. 9 (HealthDay News) -- Adempas (riociguat) has been approved by the U.S. Food and Drug Administration to treat two types of pulmonary hypertension, characterized by high blood pressure in the arteries of the lungs.

The chronic, disabling disease forces the heart to work harder than usual, and can lead to death or the need for a lung transplant, the FDA said in a news release.

Adempas, among a class of drugs called soluble guanylate cyclase stimulators, relaxes the arteries. This increases blood flow and eases blood pressure, the agency said.

The drug was approved for people with chronic thromboembolic pulmonary hypertension (CTEPH) after surgery, or for people who cannot have surgery, to help improve the ability to exercise. The drug also was approved for people with pulmonary arterial hypertension (PAH) of various causes.

Adempas was evaluated in a clinical study involving 261 people with CTEPH. People who were treated with the drug were able to walk about 150 feet further in six minutes after 16 weeks of treatment than people who took a placebo, the FDA said.

In another trial of 443 people with PAH, people treated with the drug were able to walk about 118 feet further in six minutes than those who had been treated with a placebo.

The most common side effects of the drug included headache, dizziness, indigestion, tissue swelling, nausea and vomiting.

Adempas' label includes a boxed warning that pregnant women shouldn't use the drug, which can harm a growing fetus, the agency said.

The drug is marketed by Wayne, N.J.-based Bayer HealthCare Pharmaceuticals.

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