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    Sarcoidosis

    Important
    It is possible that the main title of the report Sarcoidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • Schaumann's Disease
    • Sarcoid of Boeck

    Disorder Subdivisions

    • Acute Sarcoidosis; Heerferdt-Waldenstrom and Lofgren's Syndromes (Included)
    • Subacute Sarcoidosis
    • Chronic Sarcoidosis

    General Discussion

    Sarcoidosis is a multisystem disorder that most often affects individuals between 20 and 40 years of age. Females appear to be affected more frequently than males. Sarcoidosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) consisting of certain granular white blood cells (modified macrophages or epithelioid cells) in certain organs of the body. The granulomas that are formed are thought to alter the normal structure of and, potentially, the normal functions of, the affected organ(s), causing symptoms associated with the particular body system(s) in question. In individuals with sarcoidosis, such granuloma formation most commonly affects the lungs. However, in many cases, the upper respiratory system, lymph nodes, skin, and/or eyes may be involved. In addition, in some cases, other organs may be affected, including the liver, bone marrow, spleen, musculoskeletal system, heart, salivary glands, and/or nervous system (i.e., central or peripheral nervous system).

    The range and severity of symptoms associated with sarcoidosis vary greatly, depending upon the specific organ(s) involved and the degree of such involvement. In some cases, the symptoms of sarcoidosis may begin suddenly (acute), sometimes severely, and subside in a relatively short period of time (self limited). Acute sarcoidosis is often characterized by fatigue, fever, generalized muscle aches, difficulty breathing (dyspnea), joint pain, swollen glands, skin eruptions, eye irregularities, and/or other symptoms. In the subacute form, affected individuals may experience no symptoms (asymptomatic), even with organ involvement. In the chronic form of sarcoidosis, symptoms may appear slowly and subtly, and may persist or recur over a long time span. Initial symptoms of the chronic form of the disorder may include difficulty breathing (dyspnea), dry cough, limited airflow, and other respiratory abnormalities. Symptoms associated with other organ involvement may follow.

    The exact cause of sarcoidosis is not known. However, possible infectious, environmental, genetic, and immunological factors are under investigation as potential causes of the disorder.

    Resources

    American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Ave.
    Eastpointe, MI 48021
    Tel: (586)776-3900
    Fax: (586)776-3903
    Tel: (800)598-4668
    Email: aarda@aarda.org
    Internet: http://www.aarda.org/

    American Lung Association
    1301 Pennsylvania Ave NW
    Suite 800
    Washington, DC 20004
    USA
    Tel: (202)785-3355
    Fax: (202)452-1805
    Tel: (800)586-4872
    Email: info@lungusa.org
    Internet: http://www.lungusa.org

    NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
    Information Clearinghouse
    One AMS Circle
    Bethesda, MD 20892-3675
    USA
    Tel: (301)495-4484
    Fax: (301)718-6366
    Tel: (877)226-4267
    TDD: (301)565-2966
    Email: NIAMSinfo@mail.nih.gov
    Internet: http://www.niams.nih.gov/

    NIH/National Eye Institute
    31 Center Dr
    MSC 2510
    Bethesda, MD 20892-2510
    United States
    Tel: (301)496-5248
    Fax: (301)402-1065
    Email: 2020@nei.nih.gov
    Internet: http://www.nei.nih.gov/

    NIH/National Heart, Lung and Blood Institute
    P.O. Box 30105
    Bethesda, MD 20892-0105
    Tel: (301)592-8573
    Fax: (301)251-1223
    Email: nhlbiinfo@rover.nhlbi.nih.gov
    Internet: http://www.nhlbi.nih.gov/

    National Sarcoidosis Resource Center
    P.O. Box 1593
    Piscataway, NJ 08855-1593
    Tel: (732)699-0733
    Fax: (732)699-0882
    Email: sconroy846@aol.com
    Internet: http://www.nsrc-global.net

    Sarcoid Networking Association
    12619 S. Wilderness Way, Molalla, Oregon 97038
    aghsarc@yahoo.com
    Tacoma, WA 98408-3535
    Tel: (541)905-2092
    Email: sarcoidinformation@sarcoidosisnetwork.org
    Internet: http://www.sarcoidosisnetwork.org

    Sarcoidosis Online Sites (S.O.S.)
    P.O. Box 150549
    Cape Coral, FL 33915
    Tel: (239)945-2414
    Email: SarcoidosisOnlineSites@gmail.com
    Internet: http://www.sarcoidosisonlinesites.com

    Sarcoidosis Center
    6005 Park Ave
    Suite 501
    Memphis, TN 38119
    USA
    Tel: (901)761-5877
    Fax: (901)761-2280
    Email: sarcoid@sarcoidcenter.com
    Internet: http://www.sarcoidcenter.com

    Ocular Immunology and Uveitis Foundation
    5 Cambridge Center
    8th Floor
    Cambridge, MA 02142
    Tel: (617)621-6377
    Fax: (781)431-2042
    Tel: (866)353-6377
    Email: fosters@comcast.net
    Internet: http://www.uveitis.org

    Foundation for Sarcoidosis Research
    1820 West Webster Avenue
    Suite #304
    Chicago, IL 60614
    USA
    Tel: (312)341-0500
    Fax: (312)322-9808
    Tel: (866)358-5477
    Email: info@stopsarcoidosis.org
    Internet: http://www.stopsarcoidosis.org

    Erythema Nodosum Yahoo Support Group
    Internet: http://health.groups.yahoo.com/group/erythema_nodosum_Group/

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Center for Peripheral Neuropathy
    University of Chicago
    5841 South Maryland Ave, MC 2030
    Chicago, IL 60637
    Tel: (773)702-5659
    Fax: (773)702-5577
    Internet: http://peripheralneuropathycenter.uchicago.edu/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Autoimmune Information Network, Inc.
    PO Box 4121
    Brick, NJ 08723
    Fax: (732)543-7285
    Email: autoimmunehelp@aol.com

    European Society for Immunodeficiencies
    1-3 rue de Chantepoulet
    Geneva, CH 1211
    Switzerland
    Tel: 410229080484
    Fax: 41229069140
    Email: esid@kenes.com
    Internet: http://www.esid.org

    Janine Sarcoidosis Outreach Foundation
    12600 Bissonnet
    A4
    Houston, TX 77099
    Tel: (832)248-6621
    Fax: (281)568-5775
    Tel: (800)846-5158
    Email: sarcoidosis@jsof.org
    Internet: http://www.jsof.org/

    AutoImmunity Community
    Email: moderator@autoimmunitycommunity.org
    Internet: http://www.autoimmunitycommunity.org

    National Sarcoidosis Organization
    RR#1
    Sundre
    Alberta, T0M 1X0
    Canada
    Tel: 4035569833
    Email: info@nationalsarcoidosisorganization.com
    Internet: http://www.nationalsarcoidosisorganization.com

    Sarcoidosis & Lyme Disease Support Australia
    PO Box 629
    Narellan, NSW 2567
    Australia
    Tel: 488603532
    Email: support@sarcoidosisaustralia.com
    Internet: http://www.sarcoidosisaustralia.com

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 5/2/2008
    Copyright 1986, 1992, 1993, 1996, 1997, 1998, 1999, 2002, 2004 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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