Birth Control Pills May Raise Lupus Risk

Researchers Say Pill May Interact With Genetic Predisposition to Slightly Boost Lupus Risk

From the WebMD Archives


Oral Contraceptives and Lupus: Study Statistics, Perspective

While the overall risk of birth control pill use and lupus was boosted by 50%, or 1.5 times, Suissa says, the risk went up by 2.5 times among new users, during the first three months.

He also found that the higher doses of pills -- those with 50 micrograms of estrogen or more -- was associated with a higher risk of lupus than the lowest dose -- those with 30 micrograms or less of estrogen.

Those who took the highest dose pills had a 2.9 times increased risk of lupus, while those who took the lowest had a 1.4 times higher risk, he says.

Even so, Suissa says, the overall risk of getting lupus is still small. "In the general population, lupus will appear in six people per 100,000 per year," he says. "If you say, 'OK, let's assume all these women are using the pill, this will go to nine," he says, referring to the finding of a 50% increased overall risk of lupus associated with pill use.

"The benefits of the pill are certainly very high," he says. "Compared to these risks [of lupus], our study makes it clear that with the newer pills, at the lower doses, that in essence this risk is almost nonexistent."

The study suggests that "the risk for oral contraceptives causing lupus is there but it's small," says Bevra Hahn, MD, chief of rheumatology and arthritis at the University of California Los Angeles David Geffen School of Medicine and a member of the medical-scientific advisory council for the Lupus Foundation. .

The finding about higher-dose pills boosting the risk of lupus more than low-dose pills is new, Hahn says. The take-home point? "The lower the estrogen content you can manage, the less likely [the pill] is to cause lupus in someone who doesn't have it," she says.

Industry Comment

''There is no well-established link between combined oral contraceptive use and the development of lupus," says Rose Talarico, a spokeswoman for Bayer HealthCare Pharmaceuticals, based in Wayne, N.J. which makes two types of birth control pills.

But, she adds, the labeling for combined oral contraceptives does caution that persistent lupus can be made worse with use of the pills.

Many lower-dose options are available these days, she says. Bayer, for instance, makes Yaz and Yasmin; both have 30 micrograms or less of estrogen, she says.

WebMD Health News Reviewed by Louise Chang, MD on April 13, 2009



Samy Suissa, PhD, professor of epidemiology, McGill University, Montreal.

Bernier, M. Arthritis & Rheumatism, April 15, 2009, vol. 61: pp 476-81.

Bevra Hahn, MD, chief of rheumatology and arthritis, University of California Los Angeles David Geffen School of Medicine; member, medical-scientific advisory council, Lupus Foundation.

Rose Talarico, spokeswoman, Bayer HealthCare Pharmaceuticals, Wayne, N.J.

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