About 1 out of 3 people with lupus produce an antibody that attacks certain blood-clotting factors, which can cause the blood to clot easily.1 A person who has this antibody and has had blood clots is said to have antiphospholipid antibody syndrome. This can lead to mild or severe blood-clotting complications, including:
- Stroke, transient ischemic attack (TIA), or heart attack.
- Deep vein thrombosis or pulmonary embolism.
- Multi-infarct dementia.
- Gangrene of fingers or toes.
- Kidney disease.
- Preeclampsia, premature birth, and miscarriage or stillbirth, apparently caused by blood circulation problems in the placenta.
A blood test can detect antiphospholipid antibodies. When diagnosed, the condition is usually treated with anticoagulants. Pregnant women with antiphospholipid antibody syndrome need to be closely monitored.