Stem cell transplantation is the replacement of damaged
bone marrow cells with healthy cells, or stem cells. It is generally done after
powerful drugs have been used to wipe out the damaged immune system
Stem cells are immature cells that are produced
in the bone marrow. They can divide to produce more stem cells or mature into
red blood cells, white blood cells, and platelets.
Lupus is a difficult disease to diagnose because its symptoms can be vague. And unlike some other diseases, it cannot be diagnosed with a single lab test. However, when certain clinical criteria are met, lab tests can help confirm a diagnosis of lupus. Blood work and other tests can also help monitor the disease and show the effects of treatment.
WebMD takes a look at the uses and limitations of the tests that are commonly used to diagnose and monitor lupus.
Stem cell transplantation has serious
risks. After a person's stem cells have been collected from the bloodstream,
they are returned to the bloodstream along with a stem cell growth factor. If
successful, the stem cells help the bone marrow return to a healthy state.
But during the two weeks that the
immune system requires to become strong again, the
body is extremely vulnerable to life-threatening infection.
Small studies of stem cell transplantation for people with severe lupus have shown that it may help some people but it also has serious side effects.1 This procedure is considered a high-risk, expensive,
and experimental treatment for lupus.