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Melanoma/Skin Cancer Health Center

Medical Reference Related to Melanoma Skin Cancer

  1. Skin Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - General Information About Skin Cancer

    Skin cancer is a disease in which malignant (cancer) cells form in the tissues of the skin. The skin is the body’s largest organ. It protects against heat,sunlight,injury,and infection. Skin also helps control body temperature and stores water,fat,and vitamin D. The skin has several layers,but the two main layers are the epidermis (upper or outer layer) and the dermis (lower or inner ...

  2. Melanoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular and Molecular Classification of Melanoma

    Following is a list of clinicopathologic cellular subtypes of malignant melanoma. These should be considered descriptive terms of historic interest only as they do not have independent prognostic or therapeutic significance. Superficial spreading.Nodular.Lentigo maligna.Acral lentiginous (palmar/plantar and subungual).Miscellaneous unusual types: Mucosal lentiginous (oral and genital).Desmoplastic.Verrucous.Molecular characterization of melanoma is an active area of research. Activating mutations in the BRAF (V-raf murine sarcoma viral oncogene homolog B1) gene, first reported in 2002, are the most frequent mutation in cutaneous melanoma. Approximately 40% to 60% of malignant melanomas harbor a single nucleotide transversion. The majority have a mutation that results in a substitution from valine to glutamic acid at position 600 BRAF (V600E); less frequent mutations include valine 600 to lysine or arginine residues (V600K/R).[1] Drugs that target this mutation by inhibiting BRAF are

  3. Skin Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - What is prevention?

    Cancerprevention is action taken to lower the chance of getting cancer. By preventing cancer,the number of new cases of cancer in a group or population is lowered. Hopefully,this will lower the number of deaths caused by cancer. To prevent new cancers from starting,scientists look at risk factors and protective factors. Anything that increases your chance of developing cancer is called a ...

  4. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Changes to This Summary (03 / 29 / 2013)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Changes were made to this summary to match those made to the health professional version.

  5. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Melanoma

    Melanoma is a disease in which malignant (cancer) cells form in the skin cells called melanocytes (cells that color the skin). Melanocytes are found throughout the lower part of the epidermis. They produce melanin,the pigment that gives skin its natural color. When skin is exposed to the sun,melanocytes produce more pigment,causing the skin to tan,or darken. The skin is the body’s largest ..

  6. Intraocular (Uveal) Melanoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Extraocular Extension and Metastatic Intraocular Melanoma

    Extrascleral extension usually confers a poor prognosis. For patients with gross tumor involvement of the orbit,treatment requires orbital exenteration often combined with preoperative or postoperative radiation therapy; however,there is no evidence that this radical surgery will prolong life. Most patients with localized or encapsulated extraocular extension are not exenterated. This ...

  7. Skin Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] - Description of the Evidence

    Background Incidence and mortality There are three main types of skin cancer: Basal cell carcinoma (BCC). Squamous cell carcinoma (SCC) (together with BCC referred to as nonmelanoma skin cancer [NMSC]). Melanoma. BCC and SCC are the most common forms of skin cancer but have substantially better prognoses than the less common,generally more aggressive,melanoma. NMSC is the most commonly ...

  8. Skin Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - Get More Information From NCI

    Sources of further information about Skin Cancer Prevention.

  9. Intraocular (Eye) Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000258015-nci-header

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Intraocular (Eye) Melanoma Treatment

  10. Intraocular (Uveal) Melanoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (11 / 09 / 2012)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.This summary was comprehensively reviewed and extensively revised.This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

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