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    Cancer Vaccine Ups Melanoma Survival

    Experimental Vaccine Also Fights Kidney, Colon, Other Cancers
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    Oct. 12, 2005 - A personalized cancer vaccine extends survival for some late-stage melanoma patients, research shows.

    Melanoma is very dangerous skin cancer. Advanced stage IV melanoma kills about 90% of patients within five years of diagnosis. Patients with advanced melanoma are advised to seek clinical trials of experimental treatments.

    Now one of those trials seems to be helping the healthiest of stage IV melanoma patients. These so-called stage IV M1a patients are those whose tumors have spread just below the skin or to distant lymph nodes but haven't yet penetrated other organs.

    The study tested a vaccine treatment -- Oncophage, from Antigenics Inc. -- in stage IV melanoma patients. Oncophage is made from a patient's own tumor cells. It stimulates powerful immune responses that attack tumor cells remaining in the body after surgery. Two out of three patients got the vaccine; the other third of patients got whatever current treatment their doctors thought best.

    Antigenics released early results from the study this week. Oncophage, the company says, did not help patients whose melanoma already had spread to the lung (stage IV M1b) or to other organs (stage IV M1c).

    It was a much better story for the stage IV M1a patients. These patients lived at least 50% longer than those in the doctors'-choice-of-treatment comparison group. The comparison group survived a median of 12.8 months. The M1a patients treated with Oncophage survived a median of 20.9 months.

    That's exactly the patients one would expect to respond to a cancer vaccine, says researcher John M. Kirkwood, MD, director of the melanoma center at the University of Pittsburgh Cancer Institute. Kirkwood leads the melanoma committee of the Eastern Cooperative Oncology Group, one of the largest clinical cancer research organizations in the U.S.

    "A quarter or so of patients with advanced melanoma have this manifestation of soft-skin-tissue disease that does not involve internal organs," Kirkwood tells WebMD. "In that group we saw the impact of this vaccine."

    Earlier Treatment, Better Results?

    Based on these findings, Antigenics is designing a new clinical trial to target stage IV M1a patients. The new trial may also include patients with earlier-stage disease whose melanomas have been completely removed by surgery.

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