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New Treatment for Rare Skin Cancer

Erivedge Works in Advanced Basal Cell Carcinoma; May Help Other Cancers

Erivedge Side Effects, Cost

There is of course a downside. Hedgehog is an important signaling pathway. Blocking it causes serious side effects. Overall, 12% of patients in the advanced BCC study had to stop taking the drug. And seven patients died during the clinical trial, although none of the deaths were attributed to side effects.

The Erivedge label carries a "black box" warning of the potential risks of death and severe birth defects if the drug is taken by pregnant women. Side effects of Erivedge include:

  • Muscle spasms, some of them severe.
  • Altered taste. "Food becomes tinny tasting," Oro says. "Often we see weight loss because patients don't eat as much. For cancer patients, this is not a good thing."
  • Hair loss (strong hedgehog signaling is needed to maintain hair growth).
  • Fatigue.
  • Weight loss.

Has Erivedge approval made a big impact on cancer treatment? It's too soon to say, given that relatively few patients develop advanced BCC.

"The new medication will not affect the common approach to basal cell carcinoma treatment, which is surgery," Brown University's Martin Weinstock, MD, PhD, tells WebMD. "It is the very unusual case that would merit treatment with this." Weinstock was not involved in the Erivedge studies.

Erivedge treatment costs about $75,000 for a 10-month course of treatment.


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