If you are at risk for skin cancer, take the following precautions whenever possible:
Avoid intense sun exposure by staying out of it from 10 a.m. to 2 p.m..
Outside, wear a hat with a brim, long sleeves, trousers, and sunglasses that block UV radiation.
Use UPF (Ultraviolet Protection Factor) clothing. Or use Rit Sun Guard Laundry Treatment UV Protectant.
Use a sunscreen with a sun protection factor (SPF) of 30 or higher whenever you are outside.
Report suspicious skin lesions to...
Revised text to state that some debate remains about the origin of squamous cell carcinoma (SCC); however, these cancers are likely derived from epidermal stem cells associated with the hair follicle (cited Lapouge et al. as reference 4).
Added text to state that in addition to its effects on the prevention of BCCs in patients with basal cell nevus syndrome (BCNS), vismodegib may also have a palliative effect on keratocystic odontogenic tumors (KCOTs) found in this population; an initial report indicated that the use of GDC-0449, the hedgehog pathway inhibitor now known as vismodegib, resulted in resolution of KCOTs in one patient with BCNS (cited Goldberg et al. as reference 152). Also added text to state that another small study found that four of six patients who took 150 mg of vismodegib daily had a reduction in the size of KCOTs (cited Ally et al as reference 153).
Added level of evidence 3diii.
Added text to state that collectively, over 600 unique mutations in ocular albinism-related genes have been identified.
Add text to state that three Latvian families with melanoma have a R24H substitution in the CDK4 gene arising on the same haplotype, which suggests that it could be a founder mutation in this population (cited Veinalde et al. as reference 113).
Added Aoude et al. as reference 126.
Added text to state that a study found six individuals with the E318K variant in the MITF gene in a cohort of 168 individuals with melanoma; no unaffected controls carried the variant; individuals with the E318K variant were more likely to be fair skinned, with high nevus counts and high freckling scores, and all had multiple primary melanomas (cited Sturm et al. as reference 151); there was also a high frequency of amelanotic melanomas.
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WebMD Public Information from the National Cancer Institute
May 28, 2015
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