There is a wide range of treatment approaches, including excision, radiation therapy, cryosurgery, electrodesiccation and curettage, photodynamic or laser-beam light exposure, and topical therapies. Mohs micrographic surgery is a form of tumor excision that involves progressive radial sectioning and real-time examination of the resection margins until adequate uninvolved margins have been achieved, avoiding wider margins than needed. Each of these methods is useful in specific clinical situations...
Added text about the association of intense, intermittent recreational sun exposure with melanoma and BCC, and chronic occupational sun exposure with squamous cell carcinoma. Also added text about available data regarding regular sunscreen use and skin cancer risk reduction (cited Green et al. [J Epidemiol 1999] as reference 5, Pandeya et al. as reference 6, and Green et al. [Lancet 1999] as reference 7).
Added text to state that tanning bed use has also been associated with an increased risk of BCC. Also added text about a study of 376 individuals with BCC and 390 control subjects that found a 69% increased risk of BCC in individuals who had ever used indoor tanning (cited Ferrucci et al. as reference 2).
Added level of evidence (sun-protective clothing, avoidance of sun exposure): 4aii and level of evidence (sunscreen): 1aii.
Added text to state that palmoplantar pits are a major finding in BCC and occur in 70% to 80% of individuals with basal cell nevus syndrome (BCNS); when these pits occur together with early-onset BCC and/or keratocystic odontogenic tumors, they are considered diagnostic for BCNS (cited North et al. as reference 109).
Added National Comprehensive Cancer Network as reference 141.
Added Telomerase reverse transcriptase (TERT) as a new subsection.
Added text about a study of Norwegian melanoma cases and controls that showed that CDKN2A mutation carriers had an increased risk of melanoma when they carried either the Arg160Trp or Asp84Glu MC1R variants (cited Helsing et al. as reference 128).
Added Salerni et al. as reference 139.
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September 04, 2014
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