Melanoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Resectable Stage III Melanoma Treatment
Pegylated interferon alpha-2b
In 2011, pegylated interferon alpha-2b, which is characterized by a longer half-life and can be administered subcutaneously, was approved by the U.S. Food and Drug Administration for the adjuvant treatment of melanoma with microscopic or gross nodal involvement within 84 days of complete surgical resection, including complete lymphadenectomy.
Evidence (pegylated interferon alpha-2b):
- Approval of pegylated interferon alpha-2b was based on EORTC-18991 [NCT00006249], which randomly assigned 1,256 patients with resected stage III melanoma to observation or weekly subcutaneous pegylated interferon alpha-2b for up to 5 years.[Level of evidence: 1iiDii]
- RFS, as determined by an independent review committee, was improved for patients receiving interferon (34.8 months vs. 25.5 months in the observation arm; HR, 0.82; 95% confidence interval [CI], 0.71–0.96; P = .011).
- No difference in median OS between the arms was observed (HR, 0.98; 95% CI, 0.82–1.16).
- One-third of the patients receiving pegylated interferon discontinued treatment because of toxicity.
Treatment Options Under Clinical Evaluation for Resectable Stage III Melanoma
Treatment options under clinical evaluation for patients with resectable stage III melanoma include the following:
- Adjuvant therapy that can impact OS.
- Intralesional therapies.
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III melanoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
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