Skip to content

Men's Health

Font Size

Testosterone May Protect Against Alzheimer's

Researchers Caution: Too Early to Recommend Testosterone Therapy for Prevention of Alzheimer' Disease

Prevention Trials continued...

Last November, an Institute of Medicine task force came out against large-scale testosterone prevention trials similar to the estrogen replacement therapy trials in women. Instead, the group recommended smaller trials involving only older men who had been diagnosed with low testosterone and who are not at high risk for prostate cancer.

Just as long-term estrogen replacement therapy in older women has been linked to an increased risk of breast cancer, there are concerns that men who take testosterone may be increasing their prostate cancer risk.

Alzheimer's expert Samuel Gandy, MD, PhD, says the hope is that scientists will develop a "designer" testosterone that would target the brain and not affect other organs, in the same way the designer estrogen-like compounds, such as Raloxifene (Evista), targets the bones to prevent osteoporosis.

"Theoretically we could develop a designer estrogen or testosterone that could be protective against dementia," he says.

The Alzheimer's Association spokesman, who runs the Farber Institute for Neurosciences at Philadelphia's Thomas Jefferson University, says the long-term risks vs. benefits of taking testosterone to prevent dementia will not be known until clinical trials are completed.

"Until that happens there is no medical justification for taking testosterone to lower the risk of Alzheimer's," he says. "The data just aren't there to support that as a recommendation."

1|2

Today on WebMD

man coughing
Men shouldn’t ignore.
man swinging in hammock
And how to get out it.
 
shaving tools
On your shaving skills.
muscular man flexing
Four facts that matter.
 
Food Men 10 Foods Boost Male Health
Slideshow
Thoughtful man sitting on bed
Quiz
 
Man taking blood pressure
Slideshow
doctor holding syringe
Slideshow
 

Loaded with tips to help you avoid food allergy triggers.

Loading ...

Sending your email...

This feature is temporarily unavailable. Please try again later.

Thanks!

Now check your email account on your mobile phone to download your new app.

Condom Quiz
Quiz
thumbnail_angry_couple_in_bed
Slideshow
 
man running
Quiz
older couple in bed
Video