Skip to content

Peyronie’s: What
Happens and Why

Find out more about causes,
symptoms, and links to other
conditions.

Peyronie's and
Your Sex Life

What does it mean for your
relationship?

Seeing a Doctor
for Peyronie's

Which doctor is best? This
article will get you headed in
the right direction.

Treatments

Know your treatment options
for Peyronie's.

Related Articles

Health Guide

Ask the Expert Spotlight

Ask the Expert Spotlight

Common questions about Peyronie's

View Guide
Curved Penis?

Curved Penis?

Find out about a proven treatment for adult men with a plaque that can be felt and a curve in their penis greater than 30 degrees at the start of therapy.

Talk to Your Doctor

Talk to Your Doctor

Treatment is available for Peyronie's disease in adult men with a plaque that can be felt and a curve in their penis greater than 30 degrees at start of therapy.

Find a Certified XIAFLEX Doctor

Find a certified XIAFLEX® Doctor

If you have a plaque that can be felt and a curve in your penis greater than 30 degrees, find a doctor near you who is experienced in treating Peyronie's disease with XIAFLEX®.

Find a Doctor
Previous Slide Next Slide
close

From Our Sponsor

Content under this heading is from or created on behalf of the named sponsor. This content is not subject to the WebMD Editorial Policy and is not reviewed by the WebMD Editorial department for accuracy, objectivity or balance.

Important Safety Information

What is XIAFLEX?

XIAFLEX is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

It is not known if XIAFLEX is safe and effective in children under the age of 18.

Important Safety Information For Peyronie's Disease

Do not receive XIAFLEX if you:

  • have been told by your healthcare provider that the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra)
  • have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX

XIAFLEX can cause serious side effects, including:

  1. Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.

    • After treatment with XIAFLEX, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin

    Symptoms of corporal rupture or other serious injury to your penis may include:

    • a popping sound or sensation in an erect penis
    • sudden loss of the ability to maintain an erection
    • pain in your penis
    • purple bruising and swelling of your penis
    • difficulty urinating or blood in the urine

    Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

    Do not have sex or have any other sexual activity for at least 2 weeks after the second injection of a treatment cycle with XIAFLEX and after any pain and swelling has gone away.

    XIAFLEX for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX Risk Evaluation and Mitigation Strategy (REMS) Program. For more information about the XIAFLEX REMS Program go to www.XIAFLEXREMS.com or call 1-877-942-3539.

  2. Allergic reactions. Severe allergic reactions can happen in people who receive XIAFLEX, because it contains foreign proteins.

    Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:

    • hives
    • swollen face
    • breathing trouble
    • chest pain

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, or have a bleeding problem or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure.

XIAFLEX can cause serious side effects, including increased chance of bleeding.
Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

The most common side effects with XIAFLEX for the treatment of Peyronie's disease include:

  • a small collection of blood under the skin at the injection site (hematoma)
  • swelling at the injection site or along your penis
  • pain or tenderness at the injection site, along your penis and above your penis
  • penis bruising
  • itching of your penis or scrotum (genitals)
  • painful erection
  • erection problems (erectile dysfunction)
  • changes in the color of the skin of your penis
  • blisters at the injection site
  • pain with sex
  • a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist.

Please see the accompanying full Prescribing Information and Medication Guide.

You are encouraged to report negative side effects of prescription drugs. Contact Auxilium Pharmaceuticals, Inc., at 1-877-663-0412 or the FDA at 1-800-FDA-1088 or www.FDA.gov/medwatch.

XPD-00581 © 2014 Auxilium Pharmaceuticals, Inc.
June 2014