Aug. 19, 2008 -- An enlarged prostate can cause a
host of troublesome problems for men, like constantly waking up to go to the
But new research, funded by Eli Lilly, the company that owns the rights to
the drug tadalafil, shows a daily dose of the drug may help ease some of the
urinary symptoms related to an enlarged prostate, also known as benign
prostatic hyperplasia (BPH).
Researchers, led by Claus G. Roehrborn, MD, with the University of Texas
Southwestern Medical Center, studied 1,058 men from 10 countries. All of the
men reported urinary symptoms from BPH for at least six months, whether or not
they had a history of erectile dysfunction.
Symptoms of BPH include:
Having to urinate frequently and urgently
Having to urinate at night
A straining sensation while urinating
Still feeling the urge to urinate or a full bladder even after going to the
A weak urine stream
These lower urinary tract symptoms "increase with age with an overall
prevalence of greater than 50% in men 50 years or older," according to study
authors in the article published with the findings.
All were first given four weeks of a placebo pill.
Then they were put into five groups. Four of those groups received different
daily doses of tadalafil: 2.5 mg, 5 mg, 10 mg, or 20 mg of the drug. One group
got a dummy pill.
All the participants were scored for prostate-related urinary symptoms
before and after the study.
Researchers found that symptom scores were significantly improved at 4, 8,
and 12 weeks for those men who took the drug.
The National Kidney and Urological Disease Information Clearinghouse reports
that having an enlarged prostate is the most common prostate problem for men
over age 50.
Of men aged 51 to 60, about half will have BPH. For men over 80, that figure
shoots up to 90%, according to the American Urological Association (AUA).
The results will appear in the October edition of The Journal of