Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier
WebMD

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine
WebMD

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion
    WebMD

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community
    WebMD

    Community

    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Menopause Health Center

Font Size
A
A
A

Red Clover Fails as Hot Flash Remedy

Red Clover-Based Dietary Supplements Don't Cool Menopausal Symptoms

WebMD Health News

July 8, 2003 -- Dietary supplements containing red clover aren't likely to cool hot flashes or provide an effective alternative to hormone therapy for women seeking relief from menopausal symptoms. A major new study shows the widely advertised supplements containing plant-based, estrogen-like substances called isoflavones are no more effective than a placebo pill in reducing hot flashes.

The study appears in the July 9 issue of The Journal of the American Medical Association.

Researchers say hot flashes are the main reason women seek medical help for menopausal symptoms. Until recently, hormone replacement therapy (HRT) had been the standard treatment for hot flashes and other menopause-related symptoms. But since the Women's Health Initiative and other studies have shown that HRT can increase a woman's risk of breast cancer and heart disease, there has been a heightened need for effective alternatives to HRT in reducing symptoms and improving the quality of life for postmenopausal women.

Researchers say dietary supplements containing isoflavones derived from red clover or soy have been heavily marketed as alternative treatments for menopausal symptoms. Isoflavones are plant estrogens that have estrogen-like activity in the body. Isoflavones are the most common form of plant estrogens.

Although previous studies have examined soy-based supplements, researchers say less is known about isoflavone supplements derived from red clover, which contain additional isoflavones not found in soy that may have some effect in reducing hot flashes.

Putting Red Clover to the Test

In this study, researchers compared the effects of two different commercial red clover extracts, Promensil (82 mg of isoflavones per day) and Rimostil (57 mg of isoflavones per day), vs. a placebo in reducing hot flashes among 246 postmenopausal women who were experiencing at least 35 hot flashes per week.

After 12 weeks of treatment, the study found no differences in reducing the average number of hot flashes reported by the three groups. Women who received Promensil reported an average of 3.4 hot flashes per day compared with 2.7 per day for the Rimostil group and 2.8 for those on the placebo.

By the end of the study, the average percent reduction in hot flashes was also similar across the groups. Women who took Promensil reported a 41% reduction vs. 34% in the Rimostil and 36% in the placebo group.

Today on WebMD

woman walking outdoors
How to handle headaches, night sweats, and more.
mature woman holding fan in face
Symptoms and treatments.
 
woman hiding face behind hands
11 ways to keep skin bright and healthy.
insomnia
Is it menopause or something else?
 
senior couple
Video
mature woman shopping for produce
Article
 
Alcohol Disrupting Your Sleep
Article
mature couple on boat
Article
 
mature woman tugging on her loose skin
Slideshow
senior woman wearing green hat
Article
 
estrogen gene
Quiz
supplements
Article
 

WebMD Special Sections