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Menopause Health Center

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Seizure and Pain Drug May Treat Hot Flashes

Study Shows Gabapentin Is Effective in Easing Hot Flashes in Menopause
WebMD Health News
Reviewed by Laura J. Martin, MD

Oct. 6, 2010 -- An extended-release version of the seizure and pain drug gabapentin may be one step closer to becoming the first approved nonhormonal treatment for menopause-related hot flashes.

In a manufacturer-funded study, the drug Serada proved to be more effective than placebo for preventing hot flashes and reducing their severity.

The study was presented in Chicago at the annual meeting of the North American Menopause Society (NAMS).

Hormone therapy is the only FDA-approved treatment for hot flashes related to menopause, but many women are reluctant to undergo hormone therapy because its long-term use has been linked to an increased risk for breast cancer and stroke.

Gabapentin Side Effects

In earlier studies, immediate-release gabapentin was shown to be an effective treatment for hot flashes. But side effects, including dizziness and daytime sleepiness, were commonly reported by users.

Michael Sweeney, MD, who is vice president of research and development for Serada manufacturer Depomed Inc., says the company’s slow-release gabapentin formulation avoids many of these side effects.

About 60% of women who took the experimental drug in one study reported side effects, compared to about 50% of women taking placebo pills. About 8% and 18% of Serada users reported daytime sleepiness and dizziness, respectively, compared to about 3% and 8% of women who took a placebo.

“These side effects, when they did occur, tended to occur early in treatment and disappear within a few weeks,” Sweeney says.

Researchers presented findings from two studies of Serada at the NAMS meeting.

In one study, the number of daily hot flashes experienced by postmenopausal women taking 1,800 milligrams of the drug per day declined from around 10 to around 2. But a similar reduction in hot flashes was seen in women who took placebo pills instead of the slow-release gabapentin.

In the second study, about 65% of women taking Serada reported significant improvement in hot flash symptoms after 12 weeks of treatment, compared to 45% of women taking placebo.

NAMS founder and former executive director Wulf Utian, MD, says Serada does not appear to be as effective as hormonal therapy, but it may be a useful alternative treatment for women who can’t take hormones or don’t want to.

Utian is now an independent consultant and was a co-author of one of the studies.

Estrogen and estrogen-progestin drugs are about 95% effective for treating hot flashes,” he tells WebMD. “This drug was about 60% to 65% effective, which is about the same efficacy that has been reported with antidepressants [for treatment of hot flashes].”

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