May 25, 2005 (Atlanta) -- Popular antidepressants like Prozac and Zoloft can
eaters control the amount of food they eat, at least in the
short-term, researchers report.
A review of seven studies on binge eating that compared treatment with
antidepressants with a placebo showed that medications won every time, says
researcher Josue Bacaltchuk, MD, associate professor of psychiatry at the
Federal University of Sao Paulo in Brazil.
Overall, 41% of people taking antidepressants stopped bingeing after an
average of eight weeks, compared with just 22% of those taking placebo, says
His study was presented at the annual meeting of the American Psychiatric
Six of the seven studies used Prozac, Zoloft, Luvox, or Celexa. They're all
members of the class of drugs called selective serotonin reuptake inhibitors,
or SSRIs, that boost levels of serotonin, a mood-regulating chemical, in the
As many as 1 in 100 Americans suffer from binge eating disorder,
characterized by a compulsive, unhealthy need to eat, even when they are full.
Binge eaters are unable to control the amount of food they eat. They are
typically distressed about their behavior, but they do not induce vomiting,
fast, or abuse laxatives or diuretics.
Binge eating episodes are associated with at least three of the following
Eating until feeling uncomfortably full
Eating when not hungry
Eating alone because of embarrassment
Feeling disgusted, depressed, or guilty after overeating
No one knows what causes the condition, yet researchers say that about half
of patients with the eating disorder have depression. It is also more common
among the severely overweight but can be found among people of any weight.
Antidepressants are "currently considered the treatment of choice for binge
eating, even though they're not approved for the condition," Bacaltchuk tells
WebMD. He says "the drugs didn't help people lose weight."
But don't throw the baby out with the bathwater, Bacaltchuk says. "If the
drug is working to control bingeing, maybe think about adding a weight loss
drug or psychotherapy," he says.
Researchers are also trying to determine if Topamax, an epilepsy drug sometimes used to
treat depression, or the weight loss drug Meridia might work even better.
Early studies suggest both drugs pack a one-two punch against binge eating
disorder and obesity, Bacaltchuk says.
Eric Holander, MD, director of the Compulsive, Impulsive and Anxiety
Disorder Program at Mt. Sinai School of Medicine in New York, agrees.
"Studies are showing that Topamax has a really whopping effect, bigger than
you'd expect with an antidepressant," Holander tells WebMD. "People binge less
frequently and eat less food when they do binge, with less distress."
SOURCES: American Psychiatric Association 2005 Annual Meeting, Atlanta, May
21-26, 2005. Josue Bacaltchuk, MD, associate professor of psychiatry, Federal
University of Sao Paulo, Brazil. Eric Holander, MD, director, Compulsive,
Impulsive and Anxiety Disorder Program, Mt. Sinai School of Medicine, New York.
WebMD Medical Reference provided in collaboration with The Cleveland Clinic:
"Weight Loss: Binge Eating."