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Two Antidepressants Effective for Binge-Eating Disorder

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WebMD Health News

Dec. 2, 1999 (New York) -- Up to 1 million people in the United States suffer from binge-eating disorders, going through episodes where they feel the compulsive need to eat, to stuff themselves. Afterward, they're often left feeling out of control, ashamed, depressed, and obese. Professional care is usually needed to break the cycle, but to date there are no standard treatment programs for this specific eating disorder. Now, there is more evidence that some common antidepressants may help.

Many doctors believe that eating disorders share a common biological link with other conditions such as depression and anxiety, which if true would mean similar treatments could be effective. For some people, depression and anxiety can be controlled by taking such antidepressants as Luvox (fluvoxamine) or Zoloft (sertraline). They belong to a class of drugs called selective serotonin reuptake inhibitors (SSRIs), which put more serotonin, a mood-regulating chemical, into the body.

A recent presentation at the Eating Disorders Research Society Annual Meeting in San Diego detailed two studies in which people with binge-eating disorder responded favorably to the two medications. Both drugs led to overall improvement when compared with a placebo.

"Over the last decade or two, the eating-disorder community has recognized that there are groups of people who engage in compulsive bingeing behavior ... but don't engage in the purging behavior that is characteristic of bulimia nervosa. ... [Binge-eating disorder] is associated with lots of symptoms of depression and anxiety. ... It is certainly abnormal, very troublesome, and is associated with mental health problems," researcher James I. Hudson, MD, tells WebMD. Hudson was involved in one of the studies; he is the associate chief of biological psychiatry at McLean Hospital in Boston and is also affiliated with Harvard Medical School.

Since SSRIs have been useful for bulimia, Hudson says that it was a natural extension to see if these types of medications could also work for binge-eating disorders.

Sharon Alger-Mayer, MD, with the obesity and eating disorder program at Albany Medical College in New York, believes that the results support a chemical link between eating disorders and anxiety and depression.

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