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Mental Health Center

Marijuana-Like Compound Banishes Fear

Study Points to New Treatments for Anxiety, PTSD
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Aug. 2, 2002 -- What makes fearful memories go away? It's a natural brain chemical similar to the active ingredient in marijuana, mouse studies suggest.

The findings may lead to new treatments for people who experience overwhelming but inappropriate fear. Such fears are a hallmark of posttraumatic stress disorder (PTSD) and other anxiety disorders such as obsessive-compulsive disorder.

The report in the Aug. 1 issue of the journal Nature focuses on what now is known as the cannabinoid system. It's named after cannabis, or marijuana. Recent studies show that the human body makes its own cannabis-like substances, called cannabinoids. The brain is chock-full of tiny switches -- receptors -- that set off complex chains of events when cannabinoids turn them on. Cannabinoids play important natural roles in pain, in control of movement, and in memory.

Beat Lutz, PhD, a researcher at the Max Planck Institute in Munich, Germany, and colleagues gave mice a drug that blocked the effects of these natural cannabinoids. Since marijuana impairs memory, they guessed that blocking cannabinoids would make it easier for mice to learn.

"But no, that is not what we saw," Lutz tells WebMD. "There was no effect on memory acquisition. We saw an effect only on processing of recalled memory. It was very surprising."

There was no difference between normal mice and cannabinoid-blocked mice in their ability to learn to fear a musical tone heard at the same time they received a painful electric shock. For a long time, the animals freeze in fear when they hear the tone. When no more shocks occur, normal mice eventually forget to fear the tone -- an important process called extinction. But without brain cannabinoids, mice never learned to forget their fear.

What makes this interesting is that extinction of fearful memories is very important to humans. It's good to respond to fear at the appropriate time -- when in combat, for example. But people with PTSD can't stop reacting to things that evoke fearful memories, even when they are in a totally safe place. People with obsessive-compulsive disorder also have extinction problems. Driven by their anxieties, they can't stop repeating the same actions over and over again.

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