Low Brain Oxygen Ups Alzheimer's Risk
Lab Mice Living in Low Oxygen Show Worse Memory, More Brain Plaque
Nov. 20, 2006 -- Low levels of brain oxygen may boost Alzheimer's risk, a
new study in mice shows.
Researchers included Weihong Song, MD, PhD, of the psychiatry department and
Brain Research Centre at Canada's University of British Columbia.
Song's team studied mice that had a gene tied to Alzheimer's
The researchers kept some mice in cages with low-oxygen air for 16 hours a
day for a month.
They kept the other mice in cages with normal oxygen levels.
In humans, conditions such as stroke that hamper blood
flow in the brain can limit the brain's oxygen supply.
After the month, the researchers tested both sets of mice on a memory test
in which they were timed while swimming through a water maze to reach a hidden
The mice that had lived in low oxygen performed worse.
Those mice also had more amyloid beta plaque -- a hallmark of Alzheimer's
disease -- in their brains, compared to the mice with normal brain oxygen
Song and colleagues also studied the mice's genes.
Under the influence of low brain oxygen levels, the BACE1 gene upped
production of amyloid beta, the key protein in Alzheimer's brain plaque.
Even a "slight" rise in BACE1 activity "could lead to a dramatic
increase in [amyloid beta] production," the researchers write.
Low brain oxygen levels might also affect other genes and may spur brain
cell death, worsening memory in Alzheimer's disease, Song's team notes.
Boosting brain oxygen levels may benefit Alzheimer's patients, the
researchers say. However, their study did not test that theory.
The report appears in Proceedings of the National Academy of
Sciences' online early edition.