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Clues to Road Rage May Be in the Blood

Study finds link between levels of inflammation and explosive disorder
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WebMD News from HealthDay

By Kathleen Doheny

HealthDay Reporter

WEDNESDAY, Dec. 18, 2013 (HealthDay News) -- Recurrent, unwarranted blow-ups such as road rage may have a biological basis, according to a new study.

Blood tests of people who display the hostile outbursts that characterize a psychiatric illness known as intermittent explosive disorder show signs of inflammation, researchers say.

"What we show is that inflammation markers [proteins] are up in these aggressive individuals," said Dr. Emil Coccaro, professor and chair of psychiatry and behavioral neuroscience at the University of Chicago.

Currently, medication and behavior therapy are used to treat intermittent explosive disorder, which affects about 16 million Americans, according to the U.S. National Institute of Mental Health. But these methods are effective in fewer than 50 percent of cases, the study authors noted.

Coccaro now wants to see if anti-inflammatory medicines can reduce both unwarranted aggression and inflammation in people with this disorder.

Meanwhile, he said, it's important for those with the condition to seek treatment, rather than expect loved ones and others to live with the episodes of unwarranted hostility.

Experts began looking at inflammation and its link to aggressive behavior about a decade ago, Coccaro said. The new research, published online Dec. 18 in JAMA Psychiatry, is believed to be the first to show that two indicators of inflammation are higher in those diagnosed with the condition than in people with other psychiatric disorders or good mental health, he said.

The body-wide inflammation also puts these people at risk for other medical problems, including heart attack, stroke and arthritis, Coccaro noted.

Still, it's not known if inflammation triggers aggression or if repeated acts of aggression lead to inflammation, Coccaro said. Although the two are linked, the study does not establish a cause-and-effect relationship.

Initial controversy about whether intermittent explosive disorder is a "real" illness has subsided as more research has been done, Coccaro added.

Those diagnosed with the condition have episodes of impulsivity and aggression that are way out of proportion to the stressor. They lose control, breaking property or trying to hurt people. For example, they might blow up at a store clerk for moving too slowly or making a minor mistake.

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