Antidepressants and Other Drugs to Prevent Headaches

Along with traditional headache medications, other drugs -- like antidepressants -- can help you have fewer and less-severe headaches.

Generic Name Brand Name Possible Side Effects
Amitriptyline Elavil Fatigue, dry mouth, weight gain, constipation, drowsiness, and blurred vision. Older adults also may feel confusion or faintness.
Desipramine Norpramin Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain
Doxepin Sinequan Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight loss
Imipramine Tofranil Dizziness, drowsiness, dry mouth, weakness, weight gain
Nortriptyline Pamelor Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain
Protriptyline Vivactil Dry mouth, weight gain, constipation

Other Antidepressants Used in Headache Prevention

Generic Name Brand Name Possible Side Effects
Fluoxetine Prozac Nausea, dry mouth, appetite changes, agitation
Nefazodone Serzone Blurred vision, lightheadedness, clumsiness, ringing in the ears, skin rash, itching
Paroxetine Paxil Fatigue, weight gain
Sertraline Zoloft Insomnia, restlessness
Venlafaxine Effexor Vision changes, low sex drive, headaches
Citalopram Celexa Drowsiness, nausea, insomnia, dry mouth, sweating
Escitalopram Lexapro Ejaculating too fast or too slow, insomnia, headache, drowsiness, diarrhea, nausea
Trazodone Desyrel Dizziness, lightheadedness, drowsiness, dry mouth, headache, nausea and vomiting, a bad taste in your mouth
Bupropion Wellbutrin Agitation, anxiety, buzzing or ringing in ears, skin rash, hives, itching
Phenelzine Nardil Chills, cold sweats, confusion, dizziness or lightheadedness when you get up, overactive reflexes

 

 

WebMD Medical Reference Reviewed by David T. Derrer, MD on December 26, 2015

Sources

SOURCE: Drugs.com.

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