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    Antidepressants and Other Drugs to Prevent Headaches

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    Along with traditional headachemedications, other drugs -- like antidepressants -- can help you have fewer and less-severe headaches.

    Generic Name Brand Name Possible Side Effects
    Amitriptyline Elavil Fatigue, dry mouth, weight gain, constipation, drowsiness, and blurred vision. Older adults also may feel confusion or faintness.
    Desipramine Norpramin Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain
    Doxepin Sinequan Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight loss
    Imipramine Tofranil Dizziness, drowsiness, dry mouth, weakness, weight gain
    Nortriptyline Pamelor Dizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain
    Protriptyline Vivactil Dry mouth, weight gain, constipation

    Other Antidepressants Used in Headache Prevention

    Generic Name Brand Name Possible Side Effects
    Fluoxetine Prozac Nausea, dry mouth, appetite changes, agitation
    Nefazodone Serzone Blurred vision, lightheadedness, clumsiness, ringing in the ears, skin rash, itching
    Paroxetine Paxil Fatigue, weight gain
    Sertraline Zoloft Insomnia, restlessness
    Venlafaxine Effexor Vision changes, low sex drive, headaches
    Citalopram Celexa Drowsiness, nausea, insomnia, dry mouth, sweating
    Escitalopram Lexapro Ejaculating too fast or too slow, insomnia, headache, drowsiness, diarrhea, nausea
    Trazodone Desyrel Dizziness, lightheadedness, drowsiness, dry mouth, headache, nausea and vomiting, a bad taste in your mouth
    Bupropion Wellbutrin Agitation, anxiety, buzzing or ringing in ears, skin rash, hives, itching
    Phenelzine Nardil Chills, cold sweats, confusion, dizziness or lightheadedness when you get up, overactive reflexes

     

     

    WebMD Medical Reference

    Reviewed by David T. Derrer, MD on December 26, 2015
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