Migraines & Headaches Health Center
Transformed Migraines
Transformed migraines are chronic, daily headaches with a vascular quality (meaning that they are throbbing in nature). Most people who experience transformed migraines have a history of migraines, usually beginning in childhood or early adolescence. The onset of daily transformed migraine headaches generally occurs in people during their 20's and 30's.
Many people with a previous history of migraine will suddenly report the headaches are less severe but are more frequent, until they begin occurring daily. This change may be caused by the daily use of pain relievers. Some people with transformed migraines report having severe episodes accompanied by nausea and vomiting, much like migraines. Often, it is difficult to differentiate between tension headaches and transformed migraines.
Because transformed migraines are difficult to diagnose, many people may be treated inappropriately. Treatment is further complicated because of the chronic nature of headache. Many people with transformed headaches have the tendency to overuse pain relievers, both prescription and over-the-counter, using these drugs daily with or without having a headache. This puts the person at risk for building up a tolerance to the drugs. Additionally, taking large amounts of pain relievers containing caffeine can experience withdrawal headaches.
In many cases, people suffering from transformed migraines have other health problems such as hypertension and depression which complicate treatment. Seeking care by an experienced, multidisciplinary health care team to coordinate treatment is essential to finding relief.
Reviewed by The Cleveland Clinic Neuroscience Center.
WebMD Medical Reference provided in collaboration with the Cleveland Clinic![]()
TOPAMAX is approved for migraine prevention in adults only.
TOPAMAX is not used to stop a migraine after it starts.
IMPORTANT SAFETY INFORMATION
Serious risks associated with TOPAMAX include lowered bicarbonate levels in the blood resulting in an increase in the acidity of the blood (metabolic acidosis). Symptoms could include hyperventilation (rapid, deep breathing), tiredness, loss of appetite, irregular heartbeat or changes in the level of alertness. Call your doctor immediately if you get these symptoms. Your doctor may want to do simple blood tests. Chronic, untreated metabolic acidosis may increase the risk for kidney stones or bone disease.
Other serious risks include decreased sweating, increased body temperature, kidney stones, sleepiness, dizziness, confusion, difficulty concentrating, and increased eye pressure (glaucoma). Call your doctor immediately if you have any decrease in vision or eye pain. These problems can lead to blindness if not treated right away.
More common side effects are tingling in arms and legs, loss of appetite, tiredness, nausea, diarrhea, taste change and weight loss.
Tell your doctor about other medications you take. Please see full U.S. Prescribing Information.
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