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    Multiple Sclerosis

    Important
    It is possible that the main title of the report Multiple Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    Disorder Subdivisions

    • None

    General Discussion

    Multiple sclerosis is a chronic neuroimmunologic (both the nervous system and the immunological system are involved) disorder of the central nervous system involving the brain, spinal cord and optic nerves. By means of a mechanism not clearly understood, the protective fatty, insulating substance called myelin sheath that covers the nerve is destroyed. The inflammatory attacks that produce the characteristic scarring (plaques or patches) of the myelin sheath occurs randomly, vary in intensity, and at multiple sites. The course of the disease may advance, relapse, remit, or stabilize. The randomness of the location of plaques or patches affects the nerve's ability to transmit information (neurotransmission) and causes a wide range of neurological symptoms, which may vary from person to person.

    Recently it has been learned that the nerve fibers themselves, (axons), in addition to the myelin sheaths, are affected by the neuroimmunologic attacks. Damage to the nerve cells may be irreversible. As a result, clinicians recommend early intervention with one of the disease-modifying agents (see below).

    Resources

    WE MOVE (Worldwide Education and Awareness for Movement Disorders)
    5731 Mosholu Avenue
    Bronx, NY 10471
    USA
    Tel: (347)843-6132
    Fax: (718)601-5112
    Email: wemove@wemove.org
    Internet: http://www.wemove.org

    National Multiple Sclerosis Society
    1100 New York Avenue NW
    Suite 660
    Washington, DC 20005-3934
    USA
    Tel: (202)408-1500
    Fax: (202)408-0696
    Tel: (800)344-4867
    Email: contactusnmss@nmss.org
    Internet: http://www.nationalmssociety.org

    American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Ave.
    Eastpointe, MI 48021
    Tel: (586)776-3900
    Fax: (586)776-3903
    Tel: (800)598-4668
    Email: aarda@aarda.org
    Internet: http://www.aarda.org/

    NIH/National Institute of Neurological Disorders and Stroke
    P.O. Box 5801
    Bethesda, MD 20824
    Tel: (301)496-5751
    Fax: (301)402-2186
    Tel: (800)352-9424
    TDD: (301)468-5981
    Internet: http://www.ninds.nih.gov/

    Consortium of Multiple Sclerosis Centers
    359 Main Street
    Suite A
    Hackensack, NJ 07601
    Tel: (201)487-1050
    Fax: (201)678-2290
    Email: info@mscare.org
    Internet: http://www.mscare.org

    Multiple Sclerosis Association of America
    706 Haddonfield Road
    Cherry Hill, NJ 08002
    USA
    Tel: (856)488-4500
    Fax: (856)661-9797
    Tel: (800)532-7667
    Email: ctalbot@msassociation.org
    Internet: http://www.msassociation.org/

    Multiple Sclerosis International Federation
    3rd Floor Skyline House
    200 Union Street
    London, SE1 0LX
    United Kingdom
    Tel: 4402076201911
    Fax: 4402076201922
    Email: info@msif.org
    Internet: http://www.msif.org/en/

    Spastic Paraplegia Foundation
    5305 Miramar Ln
    Colleyville, TX 76034
    USA
    Tel: (877)773-4483
    Email: information@sp-foundation.org
    Internet: http://sp-foundation.org

    Christopher & Dana Reeve Foundation
    636 Morris Turnpike, Suite 3A
    Short Hills, NJ 07078
    USA
    Tel: (973)379-2690
    Fax: (973)912-9433
    Tel: (800)225-0292
    Email: prc@ChristopherReeve.org
    Internet: http://www.christopherreeve.org

    New Horizons Un-Limited, Inc.
    811 East Wisconsin Ave
    P.O. Box 510034
    Milwaukee, WI 53203
    USA
    Tel: (414)299-0124
    Fax: (414)347-1977
    Email: horizons@new-horizons.org
    Internet: http://www.new-horizons.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Autoimmune Information Network, Inc.
    PO Box 4121
    Brick, NJ 08723
    Fax: (732)543-7285
    Email: autoimmunehelp@aol.com

    European Society for Immunodeficiencies
    1-3 rue de Chantepoulet
    Geneva, CH 1211
    Switzerland
    Tel: 410229080484
    Fax: 41229069140
    Email: esid@kenes.com
    Internet: http://www.esid.org

    Multiple Sclerosis Foundation
    6520 North Andrews Avenue
    Ft. Lauderdale, FL 33309-2130
    Tel: (954)776-6805
    Fax: (954)938-8708
    Tel: (800)225-6495
    Email: admin@msfocus.org
    Internet: http://www.msfocus.org

    AutoImmunity Community
    Email: moderator@autoimmunitycommunity.org
    Internet: http://www.autoimmunitycommunity.org

    PLAN Institute for Caring Citizenship
    Suite 260 - 3665 Kingsway
    Vancouver
    British Columbia, V5R 5W2
    Canada
    Tel: 6044399566
    Fax: 6044397001
    Email: inquiries@planinstitute.ca
    Internet: http://www.planinstitute.ca/?q=learnfromus/library

    Child Neurology Foundation
    201 Chicago Ave, #200
    Minneapolis, MN 55415
    USA
    Tel: (952)641-6100
    Fax: (952)881-6276
    Tel: (877)263-5430
    Email: jstone@childneurologyfoundation.org
    Internet: http://www.childneurologyfoundation.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 3/29/2012
    Copyright 1984, 1985, 1986, 1987, 1988, 1989, 1990, 1991, 1992, 1993, 1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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