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    Cancer Drug Helps Hard-to-Treat MS

    Treatment Slows Disease Progression, Improves Physical Function
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    June 11, 2008 -- A 50-year-old cancer drug could help multiple sclerosis patients who have few treatment options -- those with the most aggressive and hard-to treat disease.

    In a small study published online, the chemotherapy drug cyclophosphamide was found to slow disease progression and improve physical functioning in patients with very rapidly progressing MS when given in high doses.

    All but one of the nine patients in the study had been treated unsuccessfully with conventional multiple sclerosis drugs.

    "These patients were the worst of the worst in terms of disease progression," researcher Douglas A. Kerr, MD, PhD, tells WebMD. "We were hoping that this treatment would stop progression, and it did. But we also saw something that we did not expect to see at all, which was recovery of function."

    On average, the patients were 39% less disabled at the end of almost two years of follow-up than they were prior to treatment, Kerr says.

    Treatment Targets Inflammation

    There are approximately 400,000 people in the United States living with multiple sclerosis, with 200 new cases diagnosed each week, according to the National MS Society.

    MS is widely believed to be an autoimmune disease, in which the body's own defense system attacks the coating that protects nerve fibers of the central nervous system known as myelin. When this coating is damaged or destroyed by inflammation, the nerves that carry signals to and from the brain and spinal cord no longer function properly.

    Symptoms may be mild, such as numbness in the arms and legs, or severe, leading to complete paralysis and blindness.

    The progression and severity of the disease and the response to available treatments vary greatly from patient to patient, and some patients do not respond to any of the approved treatments.

    Cyclophosphamide has been used since the late 1950s to treat cancer.

    Recently, the drug has been given experimentally in high doses along with bone marrow transplants to MS patients with very aggressive disease.

    Though the combination has been shown to be very effective in the hardest-to-treat patients, even producing cures in some, it is also highly toxic, expensive, and risky, with about 5% of patients dying as a result of the treatment, Kerr says.

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