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Multiple Sclerosis Health Center

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High Doses of Vitamin D Cut MS Relapses

Study Shows Vitamin D May Help Reduce Relapse Rate of Multiple Sclerosis

Vitamin D vs. Relapsing MS continued...

The rest of the participants were allowed to take as much vitamin D as they and their doctors thought was warranted, but it averaged out to only 1,000 IU daily.

Everyone also took 1,200 milligrams of calcium a day. Vitamin D is essential for promoting calcium absorption in the gut and together with calcium, helps promote bone health.

Vitamin D appears to suppress the autoimmune responses thought to cause MS, Burton says. In MS, haywire T lymphocytes -- the cellular "generals" of the immune system -- order attacks on the myelin sheaths that surround and protect the brain cells.

In people given high-dose vitamin D in the study, T cell activity dropped significantly. That didn't happen in people who took lower doses.

The researchers also measured the concentration of 25-hydroxyvitamin D [25(OH)D], also known as calcidiol, in the blood. The Institute of Medicine says that is the best indicator of a person's vitamin D status.

There's no ideal level, although concentrations of less than 50 nanomoles per liter of blood are considered inadequate for good health. In the study, it appeared MS patients did best if levels reached 100 nanomoles per liter, Burton says.

People with MS should talk to their doctors about whether they might benefit from vitamin D supplements, she says.

"Too much vitamin D can be harmful for people with certain medical conditions such as kidney disease," Burton says. "Also doctors can monitor your blood levels of 25(OH)D."

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