Multiple Sclerosis: Medicines for Depression - Topic Overview
Depression is the most common mental
health problem in people who have
multiple sclerosis (MS). It may result from having a
chronic disease or may be a side effect of certain MS medicines, such as
interferon beta. Depression may be treated with:
Selective serotonin reuptake inhibitors (SSRIs), such as
fluoxetine (Prozac) or sertraline (Zoloft). These medicines may also
make the person more alert and help reduce fatigue.
Tricyclic antidepressants, such as amitriptyline,
desipramine (Norpramin), or imipramine (Tofranil).
There are other antidepressant medicines in addition
to those listed above. Your doctor can help identify ones
that are best for your situation, based on your symptoms, other medicines you
are taking, and other health problems you may have.
People with secondary progressive multiple sclerosis (SPMS) start out with another type of MS -- relapsing-remitting multiple sclerosis.
If you've been diagnosed with secondary progressive MS you may have had relapsing-remitting MS for a decade or more. That's when you may begin to experience a shift in your disease.
The changes are often difficult to recognize. But you may notice that relapses may not seem to fully go away.
Most people with relapsing-remitting MS -- about 80% -- eventually develop...
FDA advisory. The U.S. Food and Drug
Administration (FDA) has issued an
advisory on antidepressant medicines and the risk of
suicide. The FDA does not recommend that people stop using these medicines.
Instead, a person taking antidepressants should be watched for
warning signs of suicide. This is especially important
at the beginning of treatment or when the doses are changed.