Symptoms may come and go
or become more or less severe from day to day or, in rare cases, from hour to hour.
Symptoms may become more severe with increased (or, less commonly, decreased)
body temperature or after a
viral infection. Symptoms of MS, such as stiffness,
tremors, pain, and difficulty thinking clearly, are similar to those of many
other conditions and do not necessarily mean you have MS.
Tysabri is approved as single therapy for the treatment of people with relapsing forms of multiple sclerosis (MS) to reduce the frequency of flare-ups and delay progression of physical disability.
After the FDA initially approved Tysabri, the drug's manufacturer took the drug off the U.S. market due to reports of a rare, but serious brain infection called PML (progressive multifocal leukoencephalopathy). But the drug returned to the market after the drugmaker included a risk-minimization program...
Muscle or motor symptoms, such as weakness, leg dragging, stiffness, a tendency to drop
things, a feeling of heaviness, clumsiness, or a lack of coordination (ataxia).
Visual symptoms, such as blurred, foggy, or hazy vision, eyeball pain
(especially when you move your eyes), blindness, or double vision. Optic
neuritis-sudden loss of vision that is often painful-is a fairly common first
symptom, occurring in up to 25% of those who have MS.
Sensory symptoms, such as tingling, a
pins-and-needles sensation, numbness, a band of tightness around the trunk or
legs, or electrical sensations moving down the back and legs.
Less common early symptoms include:
Balance symptoms, such
as lightheadedness or dizziness, and a spinning feeling (vertigo).
Bladder symptoms, such as an inability to hold urine (urinary incontinence) or to completely empty the bladder, or a loss of bladder
sensation-an inability to sense that the bladder is becoming full until there is a
sudden, urgent need to urinate.
As MS progresses, symptoms may
become more severe and may include:
Increased muscle problems, such as weakness,
leg dragging, clumsiness, or lack of coordination.
mechanical movements (spasticity) or
uncontrollable shaking (tremor), which may make walking
hard. A wheelchair may be needed some or all of the time.
and other sensory symptoms.
Incontinence or, less often, an
inability to urinate (urinary retention).