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Hormone Therapy for MS

Reviewed By: Andrew Seibert,

SOURCES: 2010 Medical Reference from Medstar Television. Rhonda Voskuhl, MD, Neurologist, University of California Los Angeles.

© 1999-2011 Medstar Television

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Narrator:

37-year-old Melissa Sherak (SHARE-ick) Glasser (GLASS-er) has had multiple sclerosis since she was a teenager.

Melissa Sherak Glasser, Patient:

My body has experienced a lot of different things from numbness to not being able to feel temperature, to not being able to use my legs, to seeing double.

Narrator:

Remarkably, during each of her four pregnancies, she saw those symptoms subside.

Melissa Sherak Glasser, Patient:

I knew there was something about being pregnant that made me feel really, really great.

Narrator:

But what exactly? In a study at U-C-L-A, researchers found that estriol (ESS-tre-uhl), a hormone produced by the placenta, plays a role.

Rhonda Voskuhl, MD, Neurologist, University of California Los Angeles:

We gave a dose of estriol to induce a pregnancy level in the patient's blood and by doing that we had recreated some of these particular effects of pregnancy.

Narrator:

In fact, in a pilot study, non-pregnant women with M-S who took an estriol pill had 80 percent fewer brain lesions - the telltale sign of the disease.

Rhonda Voskuhl, MD, Neurologist, University of California Los Angeles:

We're talking about a drug that is so safe, it's given to people that are healthy, normal individuals for birth control or menopausal symptoms.

Narrator:

The problem is it's not available in the united states - only Europe. So Doctor Voskuhl (VAH-skool) is conducting a larger study to change that.

Rhonda Voskuhl, MD, Neurologist, University of California Los Angeles:

Our goal is to acquire data, based on efficacy in MS and safety. To go to the FDA and say, what else do you need? What can we do to try to get FDA approval to bring estriol to the United States?

Narrator:

Most M-S drugs are injected and can cost up to 20-thousand dollars a year. Estriol is a pill - and much cheaper.

Rhonda Voskuhl, MD, Neurologist, University of California Los Angeles:

It's generic. It'd be on the order of $70 a year.

Narrator:

For M-S patients like Melissa it's a win-win situation. For WebMD, I'm Damon Meharg.

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