Splitting Pills Can Save Money
Some Pills Can Be Split in Half Without Losing Medicinal Effect
June 18, 2007 -- Splitting high-dose prescription tablets in half can
provide relief from high drug costs without affecting health adversely, a
University of Michigan study suggests.
The researchers there looked at the effect of splitting three high-dose
cholesterol-lowering pills in half. "Pill splitting did not make any
difference in adherence to the medications nor their cholesterol levels,"
says Hae Mi Choe, PharmD, a clinical assistant professor in the College of
Pharmacy at the University of Michigan, Ann Arbor, who is a researcher for the
study. The study is published in the June issue of The American Journal of
A pill that is twice the dose isn't typically twice the price, Choe says.
The higher-dose pills often cost only a bit more than the lower-dose ones. A
patient who needs a 40-milligram pill, for instance, might be able to split an
80-milligram tablet, doubling the supply and saving money.
Her team undertook the research because the cost of drugs can be a barrier
for patients. "Drug costs are an important determinant of whether patients
take the drugs or not," she says. This is especially true if patients are
on multiple medications, she tells WebMD.
Choe's team instructed 111 study participants who were on one of three
cholesterol-lowering medications to split the pills in half. The three drugs
were Lipitor, Pravachol, and Zocor.
She told half the participants they would get a 50% reduction in their
co-payment on each refill and the other half they would not, because she wanted
to see if the price difference would affect how well they stuck to their
medication schedule and their feelings about dealing with the minor
inconvenience of having to split the pill.
The average price reduction in the co-pay for each patient was $5 to $7 a
After six months, the researchers compared those who got a price reduction
with those who did not, asking about their willingness to continue splitting
the pills and also looking at how their cholesterol control had been
maintained. At six months, 109 of the 111 completed the survey.
"At the end of the study, we asked, 'Would you continue to pill split if
we gave you 50% off [your co-pay]," she says. "And 89% said yes they
For most, half off was enough, but 24% said they would only keep halving the
pills if the cost of the drugs to them was reduced to nothing.