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Bird Flu Jumped From Son to Father

Family Members of Bird Flu Cases May Be at Risk
WebMD Health News
Reviewed by Louise Chang, MD

April 7, 2008 -- A Chinese father, 52, barely survived bird flu he caught from his son, 24, who died.

The December 2007 cases are only the second time scientists have demonstrated probable human-to-human transmission of the H5N1 bird flu virus. But a fourth of the 378 known human cases of H5N1 bird flu have occurred in two or more "epidemiologically linked" clusters of people -- usually other family members.

Of course, family members may share exposure to sick poultry. This is by far the main way people get the virus. That's because H5N1 is still a bird virus, and has not adapted to human hosts.

However, the virus may well adapt to individuals unlucky enough to catch it from humans. Family members, are genetically similar. This means people may be at higher risk of catching the deadly virus from a relative than from someone to whom they are not related, suggest Nguyen Tran Hien, MD, MPH, PhD, of Vietnam's National Institute of Hygiene and Epidemiology, and colleagues in an editorial in the April 8 online issue of The Lancet.

"All family contacts of a patient with probable or confirmed H5N1 should be given [preventive treatment with flu drugs] and placed under surveillance," Nguyen and colleagues write. "Personal protection and advice must be extended to the family members and health workers visiting and looking after patients in the hospital."

The World Health Organization is currently following a cluster of human cases of H5N1 bird flu in Peshawar, Pakistan. Four members of this family fell ill -- three with confirmed bird flu and one with "probable" bird flu. Two died and two recovered fully.

"Laboratory tests results support ... the final risk assessment that suggested limited human-to-human transmission likely occurred among some of the family members," the WHO report states. "This outbreak did not extend into the community, and appropriate steps were taken to reduce future risks of human infections."

Father Gets Bird Flu from Son

Details on the sad case of the Chinese father and son come from Hua Wang, MD, of the Jiangsu Provincial Center for Disease Control and Prevention, and colleagues, also in the April issue of Lancet.

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