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Could Adaptable Bacteria Cause Repeat UTIs?

Study of 4 women found E. coli that 'migrated' and thrived

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Study of 4 women found E. coli that 'migrated'

By Dennis Thompson

HealthDay Reporter

WEDNESDAY, May 8 (HealthDay News) -- Women suffering from recurring urinary tract infections may carry a particularly hearty strain of E. coli bacteria that flourishes in both the gut and the bladder, and can migrate back and forth despite repeated treatments, a small new study finds.

Doctors believe that urinary tract infections are often caused by E. coli migrating from the gut to the urinary tract, according to study background information. But they have assumed that when the bacteria moves to the bladder, it loses its ability to flourish in the gastrointestinal tract.

Now the research published May 8 in the journal Science Translational Medicine suggests some strains of E. coli may be more adaptable than previously thought.

While studying a group of women who suffered from repeated episodes of urinary tract infection, the multinational team of researchers discovered strains of E. coli that can live and flourish in both the gut and the bladder.

"The idea was the ability to effectively colonize the urinary tract was inversely correlated to the ability to effectively colonize the [gastrointestinal] tract," said Michael Hibbing, a microbiologist with Washington University in St. Louis and study co-author. "We found that dichotomy wasn't necessarily true. We found one strain of E. coli that is very good at colonizing both the GI tract and the urinary tract."

More than half of all women develop at least one urinary tract infection during their lifetimes, according to the study. Up to a quarter of all women have experienced recurrent urinary tract infections -- two or more episodes within a six-month period.

The team uncovered the adaptable E. coli strains while studying 45 strains of the bacteria taken from the feces and urine of four otherwise healthy women who were experiencing successive urinary tract infection episodes.

The investigators found that two of the women were playing host to a dominant strain of E. coli that thrived in both the gut and the urinary tract during three urinary tract infections that occurred over the course of several months.

In the other two women, researchers found that the E. coli strain present in their gut and bladder changed as the patients suffered recurring urinary tract infection. The strain that caused the initial infection ended up replaced by a stronger strain that fared even better in both the urinary tract and gastrointestinal tract.

This opens the possibility that treating recurrent urinary tract infections may be more complex than previously thought, because bacteria causing the infections can move freely between the bladder and the gut, the study authors concluded.

"This is a nice high-quality piece of research that is really going to help us broaden the ideas we have about how women get and carry urinary tract infections," said Dr. Linda Brubaker, a urogynecologist and dean of the Loyola University Chicago Stritch School of Medicine. She was not involved with the new study.

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