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Multiple Egg Donations & Women's Future Fertility

Additional research found frozen eggs are nearly as effective as fresh for IVF treatments

WebMD News from HealthDay

By Mary Elizabeth Dallas

HealthDay Reporter

WEDNESDAY, Oct. 16 (HealthDay News) -- Undergoing multiple egg donations does not have a negative effect on women's future fertility, according to a preliminary new study.

This was the case even when subsequent egg-donation cycles required significantly more gonadotropin -- a drug used to stimulate ovulation -- according to researchers from Weill Cornell Medical College, in New York City.

The study involved women who completed at least five egg-donation cycles between January 2004 and April 2012. On average, the women were 26.4 years old at the time of their first egg donation. By the time of their fifth cycle, the average age of the women was 28.7 years.

In conducting the study, the researchers examined the women's anti-Mullerian hormone levels (used to measure women's response to fertility treatments), the amount of hormonal medication they received and how long they took it. They also examined how many eggs were retrieved during each egg-donation cycle.

The study revealed that, over multiple cycles, the average length of time required for stimulation ranged from 9.4 days to 10 days and the average number of eggs retrieved ranged from about 21 to 24.

"This retrospective study is reassuring in that egg donors who undergo up to six cycles do not have evidence of depleting their ovarian reserve, which bodes well for their future fertility," Dr. Linda Giudice, president of the American Society for Reproductive Medicine, said in a society news release.

On the receiving end, a separate study revealed that people who need donated eggs to conceive a child may benefit from using frozen eggs. Researchers at Seattle Reproductive Medicine found that using frozen eggs may be about as efficient as fresh eggs, as well as more cost effective.

For this study, the researchers compared the outcomes of 113 fresh donor egg in vitro fertilization (IVF) cycles with 77 frozen cycles that took place between March 2012 and February 2013.

Although pregnancy rates were 60 percent for fresh cycles and 57 percent for frozen cycles, the study revealed that patients using frozen eggs waited a shorter time from the initial medical consult to the start of a cycle: 217 days for fresh eggs, compared with 172 days for frozen eggs.

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