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New Approach May Ease Severe 'Ringing in the Ears'

Small, early study used electrical nerve stimulation and tone therapy for hard-to-treat tinnitus

WebMD News from HealthDay

By Alan Mozes

HealthDay Reporter

FRIDAY, Dec. 6, 2013 (HealthDay News) -- Patients suffering from the intense, chronic and sometimes untreatable ringing in the ear known as tinnitus may get some relief from a new combination therapy, preliminary research suggests.

The study looked at treatment with daily targeted electrical stimulation of the body's nervous system paired with sound therapy.

Half of the procedure -- "vagus nerve stimulation" -- centers on direct stimulation of the vagus nerve, one of 12 cranial nerves that winds its way through the abdomen, lungs, heart and brain stem.

Patients are also exposed to "tone therapy" -- carefully selected tones that lie outside the frequency range of the troubling ear-ringing condition.

Indications of the new treatment's success, however, are so far based on a very small pool of patients, and relief was not universal.

"Half of the participants demonstrated large decreases in their tinnitus symptoms, with three of them showing a 44 percent reduction in the impact of tinnitus on their daily lives," said study co-author Sven Vanneste. But, "five participants, all of whom were on medications for other problems, did not show significant changes."

For those participants, drug interactions might have blocked the therapy's impact, Vanneste suggested.

"However, further research needs to be conducted to confirm this," said Vanneste, an associate professor at the School of Behavioral and Brain Sciences at the University of Texas at Dallas.

The study, conducted in collaboration with researchers at the University Hospital Antwerp, in Belgium, appeared in a recent issue of the journal Neuromodulation: Technology at the Neural Interface.

The authors disclosed that two members of the study team have a direct connection with MicroTransponder Inc., the manufacturer of the neurostimulation software used to deliver vagus nerve stimulation therapy. One researcher is a MicroTransponder employee, the other a consultant. Vanneste himself has no connection with the company.

According to the U.S. National Institute on Deafness and Other Communication Disorders, nearly 23 million American adults have at some point struggled with ear ringing for periods extending beyond three months.

Yet tinnitus is not considered to be a disease in itself, but rather an indication of trouble somewhere along the auditory nerve pathway. Noise-sparked hearing loss can set off ringing, as can ear/sinus infection, brain tumors, heart disease, hormonal imbalances, thyroid problems and medical complications.

A number of treatments are available. The two most notable are "cognitive behavioral therapy" (to promote relaxation and mindfulness) and "tinnitus retraining therapy" (to essentially mask the ringing with more neutral sounds).

In 2012, a Dutch team investigated a combination of both approaches, and found that the combined therapy process did seem to reduce impairment and improve patients' quality of life better than either intervention alone.

Additional options include neural stimulation, hearing aids, cochlear implants, dietary adjustments, and/or antidepressants and anti-anxiety medications. But there is no known cure, and some patients do not respond to any treatment.

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